| Detection of Pepsin in mouth swab: correlation with clinical gastroesophageal reflux in preterm infants. | |
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MedLine Citation:
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PMID: 23311720 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract: Objective: To study the relationship between pepsinogen/pepsin in a mouth swab and clinical gastroesophageal reflux (GER) in preterm infants. Methods: Preterm infants [birth weight (BW) ≤ 2000 grams] on full enteral feeds were enrolled. Mouth swabs from cheek and below the tongue were collected 1, 2 and 3 hours after feeding. An enzymatic assay with substrate FITC-casein was used to detect pepsin A and C activity with further confirmation by Western blot. Blinded investigators reviewed the infant's medical record to clinically diagnose GER. Results: A total of 101 premature infants were enrolled. Pepsinogen/pepsin was detected in 45/101 (44.5%) infants in at least one sample. A clinical diagnosis of GER was made in 36/101 (35.6%) infants. Mouth swabs were positive in 26/36 (72%) infants with clinical GER and only 19/65 (29%) infants without GER (P<0.001). Similarly, the levels of pepsinogen/pepsin A and C were higher in the mouth swabs of infants with clinical GER. Conclusion: The detection of pepsinogen/pepsin in a mouth swab correlates with clinical GER in premature infants. |
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Authors:
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Sabeena Farhath; Zhaoping He; Judy Saslow; Sam Soundar; Barbara Amendolia; Vishwanath Bhat; Kee Pyon; Gary Stahl; Dev Mehta; Zubair H Aghai |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-13 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics/Neonatology, Cooper University Hospital, Camden, NJ. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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