Document Detail


Detection of Neurologic Injury Using Vascular Reactivity Monitoring and Glial Fibrillary Acidic Protein.
MedLine Citation:
PMID:  23420921     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
New noninvasive methods for monitoring cerebrovascular pressure reactivity coupled with a blood-based assay for brain-specific injury in preterm infants could allow early diagnosis of brain injury and set the stage for improved timing and effectiveness of interventions. Using an adaptation of near-infrared spectroscopy, we report a case of a very low birth weight infant undergoing hemoglobin volume index monitoring as a measure of cerebrovascular pressure reactivity. During the monitoring period, this infant demonstrated significant disturbances in cerebrovascular pressure reactivity that coincided with elevation of serum glial fibrillary acidic protein and new findings of brain injury on head ultrasound. This case report demonstrates the potential of emerging noninvasive monitoring methods to assist in both detection and therapeutic management to improve neurologic outcomes of the very low birth weight neonate.
Authors:
Christopher J Rhee; Kathleen K Kibler; Ken M Brady; Allen D Everett; Ernest M Graham; Dean B Andropoulos; R Blaine Easley
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-18
Journal Detail:
Title:  Pediatrics     Volume:  -     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Section of Neonatology, and.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiometabolic Risk Factors Among US Adolescents and Young Adults and Risk of Early Mortality.
Next Document:  Reasons for Earlier Than Desired Cessation of Breastfeeding.