| Detection of Iron Deposition in Dermal Fibrocytes Is a Useful Tool for Histologic Diagnosis of Nephrogenic Systemic Fibrosis. | |
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MedLine Citation:
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PMID: 21389836 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Nephrogenic systemic fibrosis (NSF) is a fibrotic disease that presents with a history of renal dysfunction. The differential diagnosis generally includes scleromyxedema, systemic sclerosis, and morphea. Especially, scleromyxedema can be extremely difficult to distinguish microscopically. Although the fibrocytes in NSF are often positive for CD34 and procollagen-I, this is not specific for NSF. We identified positive iron staining in the skin of a patient with NSF and investigated whether this was a specific feature among 9 patients with NSF reported in Japan. We found that 6 of 9 patients showed positive iron staining in the dermal fibrocytes. The amount of iron deposition seemed to have no correlation with the degree of fibrosis or duration of the skin lesions but correlated with apparent history of the use of gadolinium-based contrast agents. As controls, skin biopsies from patients with scleromyxedema, morphea, and systemic sclerosis were evaluated by iron staining. None of these control patients showed iron deposition, indicating that positive iron staining may be specific to NSF and can be a useful tool for NSF diagnosis. |
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Authors:
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Julia Miyamoto; Akiko Tanikawa; Atsuyuki Igarashi; Hiroshi Hataya; Ken Kobayashi; Masahiro Ikegami; Akihiro Sotome; Yayoi Nagai; Kaori Kameyama; Akira Ishiko |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-08 |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: - ISSN: 1533-0311 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; †Department of Dermatology, Kanto Medical Center NTT East Corporation, Tokyo, Japan; ‡Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan; §Department of Dermatology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan; ¶Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan; ∥Department of Dermatology, Dokkyo Medical University, Tochigi, Japan; **Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan; ††Department of Pathology, Keio University School of Medicine, Tokyo, Japan; and ‡‡Department of Dermatology, Toho University, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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