Document Detail


Detection of IgG, IgM and IgA antibodies in patients with uncomplicated Chlamydia trachomatis infection: a comparison between enzyme linked immunofluorescent assay and isolation in cell culture.
MedLine Citation:
PMID:  8427902     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diagnostic value of serum IgG, IgM and IgA in patients with uncomplicated urogenital Chlamydia trachomatis infection was compared with isolation in cell culture. C. trachomatis specific antibodies were determined with an enzyme linked immunofluorescent assay using elementary bodies from C. trachomatis serotypes E,F,H,I,J and LGV2 as antigens. At least two sera from each patient were tested and cultures were also established on the same day. Excluding the IgM titres in men, significantly more IgG, IgA and IgM and combinations of these antibodies were observed in culture positive patients. The sensitivity with which IgG titres in men or IgG and/or IgM titres in men and women could be determined, was significantly lower using C. trachomatis LGV2 as the only antigen than when all 6 antigens were used. The presence of 10 or more leucocytes in the urine sediment of men correlated positively with an IgG or an IgG and/or IgM titre.
Authors:
J J Theunissen; B Y van Heijst; R A Chin-A-Lien; J H Wagenvoort; E Stolz; M F Michel
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of STD & AIDS     Volume:  4     ISSN:  0956-4624     ISO Abbreviation:  Int J STD AIDS     Publication Date:    1993 Jan-Feb
Date Detail:
Created Date:  1993-03-05     Completed Date:  1993-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007917     Medline TA:  Int J STD AIDS     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM; X    
Affiliation:
Department of Dermato-Venereology, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Bacterial / analysis*
Cells, Cultured
Chlamydia Infections / diagnosis*,  immunology
Chlamydia trachomatis / immunology*
Female
Fluorescent Antibody Technique
Humans
Immunoenzyme Techniques
Immunoglobulin A / analysis*
Immunoglobulin G / analysis*
Immunoglobulin M / analysis*
Male
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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