| Detection of Helicobacter pylori and Chlamydia pneumoniae DNA in human coronary arteries and evaluation of the results with serologic evidence of inflammation. | |
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MedLine Citation:
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PMID: 16047055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Atherosclerosis is pathologically similar to a chronic inflammatory response. Recent reports have suggested that Chlamydia pneumoniae (C. pneumoniae) and Helicobacter pylori (H. pylori) play a role in the pathogenesis of atherosclerosis but this relation has not been confirmed on an inflammatory background. METHODS: Twenty-nine consecutive patients admitted to Suleyman Demirel University Medical School Cardiovascular Surgery Department, Isparta, Turkey between May 2002 to June 2003 were included in the study and the presence of C. pneumoniae and H. pylori DNA in atherosclerotic plaques of 14 coronary endarterectomy specimens and 15 left internal mammarian artery (LIMA) specimens as control subjects were determined by polymerase chain reaction. Serologic evidence of infection and inflammatory markers were also determined in both groups. RESULTS: Two C. pneumoniae DNA cases from the plaque group (14.3%) and 4 H. pylori DNA cases; 3 from plaque (21.4%) and one from the LIMA groups (6.7%) were detected. The C-reactive protein (mg/L) were higher in DNA positive samples of C. pneumoniae (66.58) and H. pylori (21.93) compared to DNA negatives of C. pneumoniae (8.49) and H. pylori (10.98), similarly interleukin-6 (U/L) levels were higher in DNA positive samples of C. pneumoniae (42.25) and H. pylori (56.37) compared with DNA negatives of C. pneumoniae (17.52) and H. pylori (13.28), but the differences were not statistically significant. Apolipoprotein B levels were significantly higher in C. pneumoniae immunoglobulin M positive cases (0.844 g/L) compared with negatives (0.661 g/L) (p=0.004). CONCLUSION: Chronic infections modify the serum lipid profile in a way that increases the risk of atherosclerosis. The increased titers of inflammation markers in DNA positive patients support inflammation in atherosclerosis, however, the results should be reproduced in a larger cohort. |
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Authors:
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Ali K Adiloglu; Ahmet Ocal; Rabia Can; Harun Duver; Turan Yavuz; Buket C Aridogan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Saudi medical journal Volume: 26 ISSN: 0379-5284 ISO Abbreviation: Saudi Med J Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-27 Completed Date: 2005-11-03 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 7909441 Medline TA: Saudi Med J Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 1068-74 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Suleyman Demirel University School of Medicine, Isparta, Turkey. aadiloglu@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Bacterial / blood Apolipoproteins B / blood C-Reactive Protein / metabolism Case-Control Studies Chlamydophila pneumoniae / genetics*, immunology Coronary Artery Disease / metabolism* Coronary Vessels / metabolism* DNA, Bacterial / metabolism* Female Helicobacter pylori / genetics*, immunology Humans Interleukin-6 / blood Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Apolipoproteins B; 0/DNA, Bacterial; 0/Interleukin-6; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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Saudi Med J. 2006 Mar;27(3):427; author reply 428
[PMID:
16532120
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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