Document Detail


Detection of HIV antigen and cDNA among antibody-negative blood samples in Nigeria.
MedLine Citation:
PMID:  18243259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In developing countries as many as 50% of patients for whom a transfusion is indicated are at risk of dying immediately if transfusion is withheld. It is therefore important that blood transfusion is made as safe as possible. This study was designed to assess the safety of blood transfusion in two large blood banks in Ibadan, Nigeria. Aliquots of 250 samples already screened and passed as negative for HIV-1 and -2 were collected from each of the blood banks. Samples were tested for the presence of HIV-1 antigen (ELAVIA Ag I) and the antigen-positive samples tested for the presence of specific HIV-1 antibodies by Western blot (BioRad, France). All antigen-positive samples were also subjected to PCR. HIV-1 antigen was detected in 6 (1.2%) of the 500 samples, of which 4 (0.8%) and 3 (0.6%) were Western blot-indeterminate and PCR-positive, respectively. Transfusion of HIV-contaminated blood may be contributing significantly to the spread of the virus in Nigeria. There is therefore an urgent need for an organized blood-banking system with facilities for more sensitive assays for the detection of HIV in blood to prevent transmission through transfusion.
Authors:
G N Odaibo; A Taiwo; Y A Aken'Ova; D O Olaleye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  102     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  284-7     Citation Subset:  IM    
Affiliation:
Department of Virology, University College Hospital, College of Medicine, University of Ibadan, Ibadan, Nigeria.
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MeSH Terms
Descriptor/Qualifier:
Blood Banks / standards
Blood Donors
Blood Transfusion* / standards
Blotting, Western / methods
DNA, Complementary / blood
HIV Antibodies / blood
HIV Antigens / blood*
HIV Infections / prevention & control*,  transmission
HIV Seronegativity / immunology*
HIV-1 / immunology
Humans
Nigeria
Polymerase Chain Reaction / methods
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/HIV Antibodies; 0/HIV Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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