| Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics. | |
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MedLine Citation:
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PMID: 19781443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature. |
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Authors:
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Juwon Kim; Tae Sung Park; Jaewoo Song; Kyung-A Lee; Duk Jin Hong; Yoo Hong Min; June-Won Cheong; Jong Rak Choi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 194 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 111-8 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Base Sequence Chromosomes, Human, Pair 16* Chromosomes, Human, Pair 21* Cytogenetic Analysis DNA Mutational Analysis Female Humans Leukemia, Myeloid, Acute / genetics*, pathology Male Oncogene Proteins, Fusion / genetics*, isolation & purification RNA, Messenger / genetics, isolation & purification RNA-Binding Protein FUS / genetics*, isolation & purification Translocation, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Oncogene Proteins, Fusion; 0/RNA, Messenger; 0/RNA-Binding Protein FUS; 0/TLS-ERG fusion protein, human |
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