Document Detail

Detection of Epstein-Barr virus in human colorectal cancer by in situ hybridazition.
MedLine Citation:
PMID:  12377618     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the relationship between Epstein-Barr virus (EBV) and the pathogenesis of human colorectal cancer. METHODS: The small-molecule RNA fragments of EBV was examined by in situ hybridization in colorectal cancer specimens obtained from 130 patients. RESULTS: EBV was found in the 6 of 130 colorectal cancer cases. EBV positivity was more prevalent in male patients (4/6), and the tumor tissues of the 4 EBV-positive cases were featured by obvious stromal infiltration by the lymphocytes (4/6). CONCLUSION: EBV infection might be related to the pathogenesis of some colorectal adenocarcinomas in China, and intensive lymphocyte infiltration in the stroma of the tumor tissues can be an important pathological indication of EBV infection in colorectal tumors.
Huan-Xin Liu; Yan-Qing Ding; Ya-Ou Sun; Li Liang; Yu-Fang Yang; Zong-Li Qi; Ji-Hong Liu; Ping-Xia Xiong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA     Volume:  22     ISSN:  1000-2588     ISO Abbreviation:  Di Yi Jun Yi Da Xue Xue Bao     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-14     Completed Date:  2003-01-13     Revised Date:  2006-03-02    
Medline Journal Info:
Nlm Unique ID:  9426110     Medline TA:  Di Yi Jun Yi Da Xue Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  915-7     Citation Subset:  IM    
Department of Pathology, First Military Medical University, Guangzhou 510515, China.
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MeSH Terms
Colorectal Neoplasms / complications,  virology*
Epstein-Barr Virus Infections / complications,  virology
Herpesvirus 4, Human / genetics,  isolation & purification*
In Situ Hybridization / methods
Middle Aged
RNA, Viral / analysis
Reg. No./Substance:
0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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