| Detection of Chlamydia pneumoniae in unexplained pulmonary hypertension. | |
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MedLine Citation:
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PMID: 11843318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathogenesis of primary pulmonary hypertension is still unclear. The case of a 68-yr-old female patient who complained of recurrent dizzy spells and collapses over a period of 6 weeks and died of global cardiac failure is presented. Autopsy revealed severe pulmonary hypertension, slight chronic bronchitis, and bronchiolitis as well as intra-alveolar accumulation of macrophages. Chlamydiae were detected within the pulmonary arteries and in intramural and intra-alveolar macrophages by immunofluorescence, confocal laser scanning microscopy, scanning and transmission electron microscopy. Nested-polymerase chain reaction (PCR) and nonradioactive deoxyribonucleic acid (DNA) hybridization of PCR products from pulmonary arteries revealed Chlamydia pneumoniae DNA. Chlamydia pneumoniae has already been detected in atherosclerosis and in pulmonary emphysema. It can induce proliferation of smooth muscle cells. Chlamydia pneumoniae might be relevant in aggravation of primary pulmonary hypertension and might perhaps be a trigger factor in some cases. |
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Authors:
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D Theegarten; O Anhenn; S Aretz; M Maass; G Mogilevski |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 19 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-02-14 Completed Date: 2002-07-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
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Languages: eng Pagination: 192-4 Citation Subset: IM |
Affiliation:
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Dept of Pathology, Ruhr-University Bochum, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chlamydophila pneumoniae / isolation & purification* Female Humans Hypertension, Pulmonary / microbiology* |
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