Document Detail

Detection of Chlamydia pneumoniae in unexplained pulmonary hypertension.
MedLine Citation:
PMID:  11843318     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of primary pulmonary hypertension is still unclear. The case of a 68-yr-old female patient who complained of recurrent dizzy spells and collapses over a period of 6 weeks and died of global cardiac failure is presented. Autopsy revealed severe pulmonary hypertension, slight chronic bronchitis, and bronchiolitis as well as intra-alveolar accumulation of macrophages. Chlamydiae were detected within the pulmonary arteries and in intramural and intra-alveolar macrophages by immunofluorescence, confocal laser scanning microscopy, scanning and transmission electron microscopy. Nested-polymerase chain reaction (PCR) and nonradioactive deoxyribonucleic acid (DNA) hybridization of PCR products from pulmonary arteries revealed Chlamydia pneumoniae DNA. Chlamydia pneumoniae has already been detected in atherosclerosis and in pulmonary emphysema. It can induce proliferation of smooth muscle cells. Chlamydia pneumoniae might be relevant in aggravation of primary pulmonary hypertension and might perhaps be a trigger factor in some cases.
D Theegarten; O Anhenn; S Aretz; M Maass; G Mogilevski
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  19     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-14     Completed Date:  2002-07-26     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  192-4     Citation Subset:  IM    
Dept of Pathology, Ruhr-University Bochum, Germany.
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MeSH Terms
Chlamydophila pneumoniae / isolation & purification*
Hypertension, Pulmonary / microbiology*

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