| Detection of 3-Iodothyronamine in Human Patients: A Preliminary Study. | |
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MedLine Citation:
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PMID: 22031514 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context and Objective:The primary purpose of this study was to detect and quantify 3-iodothyronamine (T(1)AM), an endogenous biogenic amine related to thyroid hormone, in human blood.Design:T(1)AM, total T(3), and total T(4) were assayed in serum by a novel HPLC tandem mass spectrometry assay, which has already been validated in animal investigations, and the results were related to standard clinical and laboratory variables.Setting and Patients:The series included one healthy volunteer, 24 patients admitted to a cardiological ward, and 17 ambulatory patients suspected of thyroid disease, who underwent blood sampling at admission for routine diagnostic purposes. Seven patients were affected by type 2 diabetes, and six patients showed echocardiographic evidence of impaired left ventricular function.Interventions:No intervention or any patient selection was performed.Main Outcome Measures:serum T(1)AM, total and free T(3) and T(4), routine chemistry, routine hematology, and echocardiographic parameters were measured.Results:T(1)AM was detected in all samples, and its concentration averaged 0.219 ± 0.012 pmol/ml. The T(1)AM concentration was significantly correlated to total T(4) (r = 0.654, P < 0.001), total T(3) (r = 0.705, P < 0.001), glycated hemoglobin (r = 0.508, P = 0.013), brain natriuretic peptide (r = 0.543, P = 0.016), and γ-glutamyl transpeptidase (r = 0.675, P < 0.001). In diabetic vs. nondiabetic patients T(1)AM concentration was significantly increased (0.232 ± 0.014 vs. 0.203 ± 0.006 pmol/ml, P = 0.044), whereas no significant difference was observed in patients with cardiac dysfunction.Conclusions:T(1)AM is an endogenous messenger that can be assayed in human blood. Our results are consistent with the hypothesis that circulating T(1)AM is produced from thyroid hormones and encourage further investigations on the potential role of T(1)AM in insulin resistance and heart failure. |
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Authors:
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Elena Galli; Maja Marchini; Alessandro Saba; Sergio Berti; Massimo Tonacchera; Paolo Vitti; Thomas S Scanlan; Giorgio Iervasi; Riccardo Zucchi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-26 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Scuola Superiore S. Anna (E.G.), 56127 Pisa, Italy; Dipartimento di Scienze dell'Uomo e dell'Ambiente (M.M., A.S., R.Z.) and Dipartimento di Endocrinologia (M.T., P.V.), University of Pisa, 56126 Pisa, Italy; Fondazione Gabriele Monasterio (S.B.), Ospedale del Cuore, 54100 Massa, Italy; Departments of Physiology and Pharmacology and Cell and Developmental Biology (T.S.S.), Oregon Health and Science University, Portland, Oregon 97239; and Istituto di Fisiologia Clinica (G.I.), 56124 Pisa, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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