Document Detail


Detection of 13C-labeled metabolites in the in vivo canine heart by B1 insensitive heteronuclear coherent polarization transfer and comparison of signal enhancement with NOE.
MedLine Citation:
PMID:  9055219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A recently developed adiabatic coherent polarization transfer enhancement technique [H. Merkle, H. Wei, M. Garwood, K. Uğurbil. J. Magn. Reson, 99, 480-494 (1992)] was employed to perform 13C spectroscopy in the intact canine heart in vivo during [2-13C]-acetate infusion into the left descending coronary artery, the results were compared with 13C spectra obtained with conventionally employed nuclear Overhauser enhancement. The results demonstrate that both methods can be performed by using surface coils to obtain in vivo 13C spectra and that coherent polarization transfer provides better enhancement than NOE for [2-13C]-acetate but not for short T2 compounds.
Authors:
H Wei; H Merkle; Y Xu; J Ellermann; K Sipprell; K Uğurbil
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  37     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-06     Completed Date:  1997-05-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetates / metabolism*
Animals
Carbon Isotopes
Citric Acid Cycle
Dogs
Magnetic Resonance Spectroscopy / methods*
Myocardium / metabolism*
Grant Support
ID/Acronym/Agency:
CA50703/CA/NCI NIH HHS; HL32427/HL/NHLBI NIH HHS; HL33600/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Acetates; 0/Carbon Isotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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