Document Detail

Detecting sodium-sensitivity in hypertensive patients: information from 24-hour ambulatory blood pressure monitoring.
MedLine Citation:
PMID:  21199997     Owner:  NLM     Status:  MEDLINE    
Sodium sensitivity is an important cardiovascular risk factor for which a diagnosis requires a time-consuming protocol, the implementation of which is often challenging for patients and physicians. Our aim was to assess the reliability of an easier approach based on data from 24-hour ambulatory blood pressure monitoring performed in hypertensive subjects during daily-life conditions and habitual diet. We enrolled 46 mild to moderate hypertensive subjects who underwent 24-hour ambulatory blood pressure monitoring during usual sodium intake. Patients were divided into 3 classes of sodium sensitivity risk on the basis of ambulatory blood pressure monitoring data: low risk if dippers and a 24-hour heart rate ≤ 70 bpm; high risk if nondippers and a 24-hour heart rate of > 70 bpm; intermediate risk with the remaining combinations (dippers with heart rate > 70 bpm or nondippers with heart rate ≤ 70 bpm). Then patients underwent a traditional sodium sensitivity test for the dichotomous classification as sodium sensitive or sodium resistant and for evaluating the sodium sensitivity index. Prevalence of sodium-sensitive patients and mean value of sodium sensitivity index were calculated in the 3 risk classes. The sodium sensitivity index markedly and significantly increased from the low-risk to the high-risk class, being equal to 19.9 ± 14.4, 37.8 ± 8.3, and 68.3 ± 17.0 mm Hg/(mol/day) in the low-risk, intermediate-risk, and high-risk classes, respectively (M ± SEM). Also, the prevalence of sodium-sensitive patients increased significantly from the low-risk class (25%) to the intermediate-risk (40%) and high-risk (70%) classes. Thus, performance of 24-hour ambulatory blood pressure monitoring in daily-life conditions and habitual diet may give useful information on the sodium sensitivity condition of hypertensive subjects in an easier manner than with the traditional sodium sensitivity test approach.
Paolo Castiglioni; Gianfranco Parati; Lorenzo Brambilla; Valerio Brambilla; Massimo Gualerzi; Marco Di Rienzo; Paolo Coruzzi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-01-03
Journal Detail:
Title:  Hypertension     Volume:  57     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-20     Completed Date:  2011-04-22     Revised Date:  2013-11-18    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
Department of Cardiology, Ospedale San Luca, Istituto Auxologico Italiano, Milan, Italy.
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MeSH Terms
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory / methods*
Heart Rate / drug effects
Hypertension / diagnosis,  etiology,  physiopathology*
Middle Aged
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Sodium Chloride, Dietary / administration & dosage*
Reg. No./Substance:
0/Sodium Chloride, Dietary
Comment In:
Hypertension. 2011 Feb;57(2):156-7   [PMID:  21199996 ]
J Hypertens. 2013 Sep;31(9):1910   [PMID:  24107667 ]
J Hypertens. 2013 Sep;31(9):1909   [PMID:  24107666 ]
J Hypertens. 2013 Sep;31(9):1910-1   [PMID:  24107668 ]

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