Document Detail


Detecting sodium-sensitivity in hypertensive patients: information from 24-hour ambulatory blood pressure monitoring.
MedLine Citation:
PMID:  21199997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium sensitivity is an important cardiovascular risk factor for which a diagnosis requires a time-consuming protocol, the implementation of which is often challenging for patients and physicians. Our aim was to assess the reliability of an easier approach based on data from 24-hour ambulatory blood pressure monitoring performed in hypertensive subjects during daily-life conditions and habitual diet. We enrolled 46 mild to moderate hypertensive subjects who underwent 24-hour ambulatory blood pressure monitoring during usual sodium intake. Patients were divided into 3 classes of sodium sensitivity risk on the basis of ambulatory blood pressure monitoring data: low risk if dippers and a 24-hour heart rate ≤ 70 bpm; high risk if nondippers and a 24-hour heart rate of > 70 bpm; intermediate risk with the remaining combinations (dippers with heart rate > 70 bpm or nondippers with heart rate ≤ 70 bpm). Then patients underwent a traditional sodium sensitivity test for the dichotomous classification as sodium sensitive or sodium resistant and for evaluating the sodium sensitivity index. Prevalence of sodium-sensitive patients and mean value of sodium sensitivity index were calculated in the 3 risk classes. The sodium sensitivity index markedly and significantly increased from the low-risk to the high-risk class, being equal to 19.9 ± 14.4, 37.8 ± 8.3, and 68.3 ± 17.0 mm Hg/(mol/day) in the low-risk, intermediate-risk, and high-risk classes, respectively (M ± SEM). Also, the prevalence of sodium-sensitive patients increased significantly from the low-risk class (25%) to the intermediate-risk (40%) and high-risk (70%) classes. Thus, performance of 24-hour ambulatory blood pressure monitoring in daily-life conditions and habitual diet may give useful information on the sodium sensitivity condition of hypertensive subjects in an easier manner than with the traditional sodium sensitivity test approach.
Authors:
Paolo Castiglioni; Gianfranco Parati; Lorenzo Brambilla; Valerio Brambilla; Massimo Gualerzi; Marco Di Rienzo; Paolo Coruzzi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-01-03
Journal Detail:
Title:  Hypertension     Volume:  57     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-20     Completed Date:  2011-04-22     Revised Date:  2013-11-18    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Ospedale San Luca, Istituto Auxologico Italiano, Milan, Italy. gianfranco.parati@unimib.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory / methods*
Female
Heart Rate / drug effects
Humans
Hypertension / diagnosis,  etiology,  physiopathology*
Male
Middle Aged
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Sodium Chloride, Dietary / administration & dosage*
Chemical
Reg. No./Substance:
0/Sodium Chloride, Dietary
Comments/Corrections
Comment In:
Hypertension. 2011 Feb;57(2):156-7   [PMID:  21199996 ]
J Hypertens. 2013 Sep;31(9):1910   [PMID:  24107667 ]
J Hypertens. 2013 Sep;31(9):1909   [PMID:  24107666 ]
J Hypertens. 2013 Sep;31(9):1910-1   [PMID:  24107668 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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