| Detecting selective expression of genes and proteins. | |
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MedLine Citation:
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PMID: 10077535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Selective expression of a gene product (mRNA or protein) is a pattern in which the expression is markedly high, or markedly low, in one particular tissue compared with its level in other tissues or sources. We present a computational method for the identification of such patterns. The method combines assessments of the reliability of expression quantitation with a statistical test of expression distribution patterns. The method is applicable to small studies or to data mining of abundance data from expression databases, whether mRNA or protein. Though the method was developed originally for gene-expression analyses, the computational method is, in fact, rather general. It is well suited for the identification of exceptional values in many sorts of intensity data, even noisy data, for which assessments of confidences in the sources of the intensities are available. Moreover, the method is indifferent as to whether the intensities are experimentally or computationally derived. We show details of the general method and examples of computational results on gene abundance data. |
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Authors:
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L D Greller; F L Tobin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Genome research Volume: 9 ISSN: 1088-9051 ISO Abbreviation: Genome Res. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-06-18 Completed Date: 1999-06-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9518021 Medline TA: Genome Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 282-96 Citation Subset: IM |
Affiliation:
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Bioinformatics-Mathematical Biology, SmithKline Beecham Pharmaceuticals Research & Development, King of Prussia, Pennsylvania 19406 USA.Larry_Greller@sbphrd.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Computational Biology / methods Gene Expression Regulation* Protein Biosynthesis* RNA, Messenger / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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