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Detecting molecular selection on single amino acid replacements.
MedLine Citation:
PMID:  22450271     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Amino acid property methods have repeatedly proven more sensitive than nucleotide-based methods, especially to the subtle influences of selection on Single Nucleotide Polymorphisms (SNPs). The purpose of this study is to evaluate the effects of population sampling and sliding window size on the sensitivity of one amino acid based method by assessing drug resistant SNPs from the HIV-1 gag-pol gene. The analysis of most of the SNPs produced positive results. There was not a trend in terms of properties affected most often, but sliding window size affected results more than population sampling.
Authors:
David A McClellan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of bioinformatics research and applications     Volume:  8     ISSN:  1744-5485     ISO Abbreviation:  Int J Bioinform Res Appl     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101253758     Medline TA:  Int J Bioinform Res Appl     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  67-80     Citation Subset:  IM    
Affiliation:
Bigelow Laboratory for Ocean Sciences, PO Box 475, 180 McKown Point Road, West Boothbay Harbor, Maine, 04575 - 0475, USA.
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