| Detecting molecular selection on single amino acid replacements. | |
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MedLine Citation:
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PMID: 22450271 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Amino acid property methods have repeatedly proven more sensitive than nucleotide-based methods, especially to the subtle influences of selection on Single Nucleotide Polymorphisms (SNPs). The purpose of this study is to evaluate the effects of population sampling and sliding window size on the sensitivity of one amino acid based method by assessing drug resistant SNPs from the HIV-1 gag-pol gene. The analysis of most of the SNPs produced positive results. There was not a trend in terms of properties affected most often, but sliding window size affected results more than population sampling. |
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Authors:
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David A McClellan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of bioinformatics research and applications Volume: 8 ISSN: 1744-5485 ISO Abbreviation: Int J Bioinform Res Appl Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101253758 Medline TA: Int J Bioinform Res Appl Country: Switzerland |
Other Details:
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Languages: eng Pagination: 67-80 Citation Subset: IM |
Affiliation:
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Bigelow Laboratory for Ocean Sciences, PO Box 475, 180 McKown Point Road, West Boothbay Harbor, Maine, 04575 - 0475, USA. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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