| Detecting mitomycin C in human plasma during intravesical therapy. | |
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MedLine Citation:
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PMID: 3936816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitomycin C (MMC) concentrations in plasma and urine were measured in five patients with intact bladder during intravesical instillation therapy. No MMC was detected in plasma by a selective high performance liquid chromatographic (HPLC) method. The detection limit of the method is 1 ng/ml. Our results are in accordance with clinical experiences of the lack of systemic toxicity during MMC instillation therapy. There was a remarkable loss of MMC in the voided urine. The probable explanation could be that a considerable amount of MMC is absorbed into the bladder wall. |
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Authors:
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K Jauhiainen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International urology and nephrology Volume: 17 ISSN: 0301-1623 ISO Abbreviation: Int Urol Nephrol Publication Date: 1985 |
Date Detail:
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Created Date: 1986-03-18 Completed Date: 1986-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: HUNGARY |
Other Details:
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Languages: eng Pagination: 155-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Aged Female Humans Male Middle Aged Mitomycin Mitomycins / administration & dosage, blood*, therapeutic use, urine Urinary Bladder Urinary Bladder Neoplasms / blood, drug therapy*, urine |
| Chemical | |
Reg. No./Substance:
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0/Mitomycins; 50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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