Document Detail


Detecting electroporation by assessing the time constants in the exponential response of human skin to voltage controlled impulse electrical stimulation.
MedLine Citation:
PMID:  19964517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We propose a new method for extracting the electrical properties of human skin based on the time constant analysis of its exponential response to impulse stimulation. As a result of this analysis an adjacent finding has arisen. We have found that stratum corneum electroporation can be detected using this analysis method. We have observed that a one time-constant model is appropriate for describing the electrical properties of human skin at low amplitude applied voltages (<30V), and a two time-constant model best describes skin electrical properties at higher amplitude applied voltages (>30V). Higher voltage amplitudes (>30V) have been proven to create pores in the skin's stratum corneum which offer a new, lower resistance, pathway for the passage of current through the skin. Our data shows that when pores are formed in the stratum corneum they can be detected, in-vivo, due to the fact that a second time constant describes current flow through them.
Authors:
Sinziana I Bîrlea; Gavin J Corley; Nicolae M Bîrlea; Paul P Breen; Fabio Quondamatteo; Gearóid OLaighin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2009     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-04-22     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1355-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biomedical Engineering
Electric Stimulation
Electroporation*
Humans
Linear Models
Models, Biological
Models, Neurological
Neuromuscular Junction / physiology
Skin / innervation
Skin Physiological Phenomena*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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