| Detecting, studying, and treating autism early: the one-year well-baby check-up approach. | |
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MedLine Citation:
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PMID: 21524759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD). STUDY DESIGN: The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants participated. Screens were scored immediately, and failures referred for further evaluation. RESULTS: Pediatricians screened 10 479 infants at the 1-year check-up; 184 infants who failed the screen were evaluated and tracked. To date, 32 infants received a provisional or final diagnosis of ASD, 56 of LD, nine of DD, and 36 of "other." Five infants who initially tested positive for ASD no longer met criteria at follow-up. The remainder of the sample was false positive results. Positive predictive value was estimated to be .75. CONCLUSIONS: The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age. |
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Authors:
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Karen Pierce; Cindy Carter; Melanie Weinfeld; Jamie Desmond; Roxana Hazin; Robert Bjork; Nicole Gallagher |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-04-27 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 159 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-17 Completed Date: 2011-11-08 Revised Date: 2012-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 458-465.e1-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA, kpierce@ucsd.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Attitude of Health Personnel Autistic Disorder / diagnosis* California Child Development Child, Preschool Developmental Disabilities / diagnosis Early Diagnosis False Positive Reactions Feasibility Studies Follow-Up Studies Humans Infant Language Development Disorders / diagnosis Mass Screening* Pediatrics Predictive Value of Tests Questionnaires |
| Grant Support | |
ID/Acronym/Agency:
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P50 MH081755-03/MH/NIMH NIH HHS; R01 MH080134/MH/NIMH NIH HHS; R01 MH080134-03/MH/NIMH NIH HHS |
| Comments/Corrections | |
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