Document Detail

Detecting, studying, and treating autism early: the one-year well-baby check-up approach.
MedLine Citation:
PMID:  21524759     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD).
STUDY DESIGN: The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants participated. Screens were scored immediately, and failures referred for further evaluation.
RESULTS: Pediatricians screened 10 479 infants at the 1-year check-up; 184 infants who failed the screen were evaluated and tracked. To date, 32 infants received a provisional or final diagnosis of ASD, 56 of LD, nine of DD, and 36 of "other." Five infants who initially tested positive for ASD no longer met criteria at follow-up. The remainder of the sample was false positive results. Positive predictive value was estimated to be .75.
CONCLUSIONS: The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.
Karen Pierce; Cindy Carter; Melanie Weinfeld; Jamie Desmond; Roxana Hazin; Robert Bjork; Nicole Gallagher
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-27
Journal Detail:
Title:  The Journal of pediatrics     Volume:  159     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-17     Completed Date:  2011-11-08     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  458-465.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
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MeSH Terms
Attitude of Health Personnel
Autistic Disorder / diagnosis*
Child Development
Child, Preschool
Developmental Disabilities / diagnosis
Early Diagnosis
False Positive Reactions
Feasibility Studies
Follow-Up Studies
Language Development Disorders / diagnosis
Mass Screening*
Predictive Value of Tests
Grant Support
P50 MH081755-03/MH/NIMH NIH HHS; R01 MH080134/MH/NIMH NIH HHS; R01 MH080134/MH/NIMH NIH HHS; R01 MH080134-03/MH/NIMH NIH HHS

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