Document Detail

Detecting graded exposure effects: a report on an East Boston pregnancy cohort.
MedLine Citation:
PMID:  22266824     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The effects of tobacco exposure are typically examined by comparing groups based on a cut-score of self-reported number of cigarettes or bioassays collected in cross-sectional studies. This study introduces a new fuzzy clustering method that facilitates detection of subtle exposure effects by objectively deriving subgroups from modeling multidimensional exposure measures. We test the new method on a known exposure effect (fetal growth) and report on the graded exposure effect detected in a pregnancy cohort.
METHODS: A total of 978 pregnant women were enrolled from 1986 to 1992 in the Maternal Infant Smoking Study of East Boston (MISSEB). Four kinds of exposure data were used to generate exposure groups: self-reported smoking, cotinine levels, nicotine levels, and nicotine dependence scores. Subgroups were identified via a comprehensive validation procedure. The results from MISSEB (number of exposure clusters, exposure effects on birth weight, body length, and head circumference) were compared with those obtained in a separate cohort.
RESULTS: Using our new method in MISSEB, the same number of clusters was generated as previously, and graded exposure effects were again detected. Neonates with heavier exposure weighed less at birth relative to nonexposed neonates, with no difference between lighter-exposed and nonexposed neonates.
CONCLUSIONS: The same graded prenatal exposure effect emerges for known exposure-related outcomes across 2 different studies, about 2 decades apart. Our new method characterizes the degree of prenatal exposure, with the potential to help detect subtler effects on developmental outcomes, such as deficits in growth or development, neonatal temperament and behavior, and psychological functioning.
Hua Fang; Vanja Dukic; Kate E Pickett; Lauren Wakschlag; Kimberly Andrews Espy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-20
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  14     ISSN:  1469-994X     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-03     Completed Date:  2013-01-24     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1115-20     Citation Subset:  IM    
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MeSH Terms
Boston / epidemiology
Cluster Analysis
Cohort Studies
Maternal Exposure / statistics & numerical data*
Pregnancy Complications / epidemiology*,  psychology
Prenatal Exposure Delayed Effects / epidemiology*,  psychology
Self Report*
Smoking / adverse effects,  epidemiology*
Tobacco Smoke Pollution / statistics & numerical data*
Young Adult
Grant Support
1UL1RR031982-01/RR/NCRR NIH HHS; CSA/03/07/014//Department of Health; DA027624-01/DA/NIDA NIH HHS; R01 014661//PHS HHS; R01 DA023653/DA/NIDA NIH HHS; R01DA15223/DA/NIDA NIH HHS
Reg. No./Substance:
0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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