Document Detail


[Detailed methodological recommendations for the treatment of Clostridium difficile-associated diarrhea with faecal transplantation].
MedLine Citation:
PMID:  23274229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of Clostridium difficile associated enteral disease shows dramatic increase worldwide, with appallingly high treatment costs, mortality figures, recurrence rates and treatment refractoriness. It is not surprising, that there is significant interest in the development and introduction of alternative therapeutic strategies. Among these only stool transplantation (or faecal bacteriotherapy) is gaining international acceptance due to its excellent cure rate (≈92%), low recurrence rate (≈6%), safety and cost-effectiveness. Unfortunately faecal transplantation is not available for most patients, although based on promising international results, its introduction into the routine clinical practice is well justified and widely expected. The authors would like to facilitate this process, by presenting a detailed faecal transplantation protocol prepared in their Institution based on the available literature and clinical rationality. Officially accepted national methodological guidelines will need to be issued in the future, founded on the expert opinion of relevant professional societies and upcoming advances in this field.
Authors:
Gergely György Nagy; Csaba Várvölgyi; Zoltán Balogh; Piroska Orosi; György Paragh
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Orvosi hetilap     Volume:  154     ISSN:  0030-6002     ISO Abbreviation:  Orv Hetil     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-03-08     Revised Date:  2013-05-07    
Medline Journal Info:
Nlm Unique ID:  0376412     Medline TA:  Orv Hetil     Country:  Hungary    
Other Details:
Languages:  hun     Pagination:  10-9     Citation Subset:  IM    
Affiliation:
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Belgyógyászati Intézet, Intenzív Terápiás Osztály Debrecen Nagyerdei. ngergely@hotmail.com
Vernacular Title:
Módszertani ajánlás a Clostridium difficile fertőzéshez asszociált hasmenés széklettranszplantációval történő kezeléséhez.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / therapeutic use
Clostridium difficile* / isolation & purification
Diarrhea / microbiology*
Enterocolitis, Pseudomembranous / complications,  therapy*
Feces*
Gastrointestinal Tract* / microbiology
Humans
Sterilization
Transplantation, Homologous / instrumentation,  methods*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents
Comments/Corrections
Comment In:
Orv Hetil. 2013 Mar 17;154(11):434-5   [PMID:  23573537 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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