Document Detail

Destruction of normal human eosinophils by Entamoeba histolytica.
MedLine Citation:
PMID:  2550874     Owner:  NLM     Status:  MEDLINE    
We evaluated the in-vitro interaction of normal human eosinophil leucocytes and a virulent strain of Entamoeba histolytica (HM1-IMSS) in the presence of immune serum. At a 10:1 (eosinophil:amoeba) ratio a significant time-dependent destruction of eosinophils was found from the first hour onward, and a similar, albeit weaker, cytopathic effect was found in the 200:1 ratio mixtures, with some delay in the microscopic evidence of such effect. Results were unaffected by serum factors, and amoebae emerged virtually unharmed throughout these experiments, again regardless of the presence of serum factors. These results indicate that, as with neutrophil leucocytes, virulent E. histolytica is capable of destroying normal human eosinophils in vitro.
M López-Osuna; R R Kretschmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasite immunology     Volume:  11     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-26     Completed Date:  1989-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  403-11     Citation Subset:  IM    
Division of Immunology, Universidad Nacional Autónoma de México, DF.
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MeSH Terms
Cell Survival
Entamoeba histolytica / immunology,  pathogenicity*
Eosinophils / immunology,  parasitology*
Immune Sera / immunology
Reg. No./Substance:
0/Immune Sera

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