Document Detail

Destruction of intracerebrally applied red blood cells in cervical lymph nodes. Experimental investigations.
MedLine Citation:
PMID:  6826120     Owner:  NLM     Status:  MEDLINE    
In rabbits, intracerebrally applied erythrocytes can move with the cerebrospinal fluid along connecting pathways between the subarachnoid space and the cervical lymph nodes. This study compares the time dependency for the degradation of intracerebrally injected erythrocytes in the brain as well as in the cervical lymph nodes. Rabbits were killed at various predetermined intervals after the intracerebral erythrocyte injection. Microscopic and histologic examination of the brain and the cervical lymph nodes revealed the following findings: (1) Erythrophages first appeared in the brain 24 h after the injection; siderophages, 4 days after the injection. Siderophages were still demonstrable at the conclusion of the study, i.e. 240 days after the injection. (2) In the cervical lymph nodes erythrophages were first observed 1 h after the injection; siderophages, 9 h after the injection. Only isolated erythrophages and siderophages were found in the lymph nodes 12 days after intracerebral injection of red blood cells. Later on no erythrocytes or siderophages were observed in the lymph nodes. The findings indicate that non-phagocytized red blood cells arriving at the lymph nodes were ingested by local macrophages. The extremely rapid ingestion and digestion of the red blood cells by lymph node macrophages as well as the possible reasons were discussed.
M Oehmichen; H Wiethölter; H Grüninger; M Gencic
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Forensic science international     Volume:  21     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:    1983 Jan-Feb
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  43-57     Citation Subset:  IM    
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MeSH Terms
Brain / physiology*
Erythrocytes / physiology*
Histiocytes / physiology
Lymph Nodes / physiology*
Macrophages / physiology
Phagocytes / physiology
Subdural Space

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