Document Detail


Destruction of catecholamine-containing neurons by 6-hydroxydopa, an endogenous amine oxidase cofactor.
MedLine Citation:
PMID:  9871458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The amino acid, 6-hydroxydopa (6-OHDOPA), found at the active site of amine oxidases, exists as a keto-enol. Exogenously administered 6-OHDOPA is an excitotoxin like beta-N-oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA), acting at the non-N-methyl-D-aspartate (non-NMDA) alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor. BMAA and BOAA are causal factors of neurolathyrism in humans. Much exogenously administered 6-OHDOPA is biotransformed by aminoacid decarboxylase (AADC) to the highly potent and catecholamine-(CA) selective neurotoxin, 6-hydroxydopamine (6-OHDA). 6-OHDOPA destroys locus coeruleus noradrenergic perikarya and produces associated denervation of brain by norepinephrine-(NE) containing fibers. Opiopeptides and opioids enhance neurotoxic effects of 6-OHDOPA on noradrenergic nerves, by a naloxone-reversible process. An understanding of mechanisms underlying neurotoxic effects of 6-OHDOPA can be helpful in defining actions of known and newfound amino acids and for investigating their potential neurotoxic properties.
Authors:
R M Kostrzewa; R Brus
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Amino acids     Volume:  14     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  1998  
Date Detail:
Created Date:  1999-01-13     Completed Date:  1999-01-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, USA.
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MeSH Terms
Descriptor/Qualifier:
Amine Oxidase (Copper-Containing)*
Animals
Catecholamines / metabolism*
Dihydroxyphenylalanine / analogs & derivatives*,  metabolism,  toxicity
Humans
Neurons / metabolism*
Oxidoreductases Acting on CH-NH Group Donors / metabolism*
Chemical
Reg. No./Substance:
0/Catecholamines; 21373-30-8/6-hydroxydopa; 63-84-3/Dihydroxyphenylalanine; EC 1.4.3.6/Amine Oxidase (Copper-Containing); EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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