| Destruction of catecholamine-containing neurons by 6-hydroxydopa, an endogenous amine oxidase cofactor. | |
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MedLine Citation:
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PMID: 9871458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The amino acid, 6-hydroxydopa (6-OHDOPA), found at the active site of amine oxidases, exists as a keto-enol. Exogenously administered 6-OHDOPA is an excitotoxin like beta-N-oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA), acting at the non-N-methyl-D-aspartate (non-NMDA) alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor. BMAA and BOAA are causal factors of neurolathyrism in humans. Much exogenously administered 6-OHDOPA is biotransformed by aminoacid decarboxylase (AADC) to the highly potent and catecholamine-(CA) selective neurotoxin, 6-hydroxydopamine (6-OHDA). 6-OHDOPA destroys locus coeruleus noradrenergic perikarya and produces associated denervation of brain by norepinephrine-(NE) containing fibers. Opiopeptides and opioids enhance neurotoxic effects of 6-OHDOPA on noradrenergic nerves, by a naloxone-reversible process. An understanding of mechanisms underlying neurotoxic effects of 6-OHDOPA can be helpful in defining actions of known and newfound amino acids and for investigating their potential neurotoxic properties. |
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Authors:
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R M Kostrzewa; R Brus |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Amino acids Volume: 14 ISSN: 0939-4451 ISO Abbreviation: Amino Acids Publication Date: 1998 |
Date Detail:
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Created Date: 1999-01-13 Completed Date: 1999-01-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 175-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amine Oxidase (Copper-Containing)* Animals Catecholamines / metabolism* Dihydroxyphenylalanine / analogs & derivatives*, metabolism, toxicity Humans Neurons / metabolism* Oxidoreductases Acting on CH-NH Group Donors / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 21373-30-8/6-hydroxydopa; 63-84-3/Dihydroxyphenylalanine; EC 1.4.3.6/Amine Oxidase (Copper-Containing); EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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