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Desquamative interstitial pneumonia may progress to lung fibrosis as characterized radiologically.
MedLine Citation:
PMID:  22805187     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY AT A GLANCE: A clinical study of patients with desquamative interstitial pneumonia was performed to assess the outcomes of long-term follow-up by high resolution computed tomography (HRCT). Of the 31 patients studied, 14 were followed-up for more than 60 months (mean 122 months). Five patients developed honeycombing on HRCT. ABSTRACT: Background and objective:  In some patients, desquamative interstitial pneumonia may progress to lung fibrosis. The aim of this study was to assess the long-term radiological follow-up results in patients with desquamative interstitial pneumonia. Methods:  Among 75 patients suspected of having desquamative interstitial pneumonia, 31 patients who fulfilled the criteria were included for this study. Clinical characteristics at presentation, responses to treatment, and long-term follow-up were evaluated. Results:  The 31 patients were predominantly males (94%), and the mean age was 55 years; 93% (28/30) had a history of smoking. The clinical findings included high serum levels of lactate dehydrogenase and immunoglobulin G. Bronchoalveolar lavage (26 patients, 84% of cases) frequently showed an increased percentage of eosinophils (mean 17%). Computed tomography (CT) or high resolution (HR)CT at presentation showed ground glass opacities and/or consolidation in all patients, with one third of patients also showing thin walled cysts within the ground glass opacities. There was no honeycombing on CT or HRCT scans at presentation. Corticosteroid therapy was effective early in the course of the disease; long-term follow-up (mean 99 months) of 31 patients showed only one death due to progression of the disease, but long-term follow-up of 14 patients (mean 125 months) by HRCT showed the development of new thin walled cysts and honeycombing in five and lung cancer in four patients respectively. Conclusions:  In a proportion of patients, desquamative interstitial pneumonia may progress to lung fibrosis with honeycombing on HRCT, despite therapy. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Authors:
Yoshinori Kawabata; Tamiko Takemura; Akira Hebisawa; Yutaka Sugita; Takashi Ogura; Sonoko Nagai; Fumikazu Sakai; Tetsu Kanauchi; Thomas V Colby;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-17
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Affiliation:
Division of Diagnostic Pathology, Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan Department of Laboratory Medicine, National Hospital Organization Tokyo Hospital, Tokyo, Department of Respiratory Medicine Department of Respiratory Medicine, Kanagawa Prefectural Cardiovascular Respiratory Center, Kanagawa, Japan Central Clinic, Research Center, Kyoto, and Department of Radiology, Saitama International Medical Center, Saitama Medical University, Saitama, Japan, Department of Radiology, Saitama Prefectural Cardiovascular and Respiratory Center, Saitama, Japan Department of Laboratory Medicine and Pathology, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA.
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