Document Detail

Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats.
MedLine Citation:
PMID:  16125522     Owner:  NLM     Status:  MEDLINE    
In contrast to humans, rats on a high-fat ketogenic diet seem incapable of maintaining plasma beta-hydroxybutyrate above 1 mmol/L for more than a week. Our goal was to determine whether fatty acid metabolism in rats changes despite the absence of sustained ketosis induced by the ketogenic diet. Fatty acid metabolism was assessed as changes in tissue fatty acid profiles and change in 13C-alpha-linolenic acid incorporation into plasma, liver, adipose tissue, and brain lipids. Despite loss of ketosis, the ketogenic diet reduced some polyunsaturated fatty acids in adipose tissue (up to 44%) and plasma (up to 90%) but raised polyunsaturates in liver triglycerides by up to 25-fold and raised arachidonic and docosahexaenoic acids in the brain by 15%. Lower tissue incorporation of 13C-alpha-linolenic acid but higher unlabeled and 13C-labeled docosahexaenoic acid in brain supports the view that the principal changes in fatty acid composition resulted from enhanced mobilization of polyunsaturates from adipose tissue to liver and brain. In the absence of sustained ketosis, changes in fatty acid metabolism resulting in an increase in brain polyunsaturates, particularly docosahexaenoic acid may, nevertheless, contribute to the seizure protection by the ketogenic diet.
Ameer Y Taha; Mary Ann A Ryan; Stephen C Cunnane
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  54     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-29     Completed Date:  2005-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1127-32     Citation Subset:  IM    
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2.
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MeSH Terms
Adipose Tissue
Arachidonic Acid / metabolism
Brain / metabolism
Carbon Isotopes / diagnostic use
Dietary Fats / pharmacology*
Docosahexaenoic Acids / metabolism
Epilepsy / diet therapy,  metabolism
Fatty Acids / blood,  pharmacokinetics*
Fatty Acids, Omega-3 / blood,  pharmacokinetics
Fatty Acids, Unsaturated / blood,  pharmacokinetics
Ketosis / metabolism*
Liver / metabolism
Rats, Wistar
alpha-Linolenic Acid / blood,  pharmacokinetics
Reg. No./Substance:
0/Carbon Isotopes; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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