Document Detail


Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis.
MedLine Citation:
PMID:  17186796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term in vitro compatibility of desoximetasone and tacrolimus ointments prompted the current trial in humans. We aimed to evaluate the efficacy of twice-daily simultaneous application of desoximetasone and tacrolimus in the treatment of atopic dermatitis versus tacrolimus monotherapy. Eighty-two subjects were treated in this multicenter, single-group, double-blinded, paired, 3-week follow-up clinical study of desoximetasone 0.25% and tacrolimus 0. 1% ointments versus tacrolimus 0.1% ointment and vehicle. Subjects were treated twice daily for 21 days or until clearing. Safety and efficacy were assessed at days 3, 7, 14, and 21. The combination of desoximetasone and tacrolimus ointment was superior to tacrolimus alone (P=.0002) in treating atopic dermatitis as measured by the summary of the scores for erythema, lichenification, pruritus, scaling/dryness, and oozing/crusting. Of note, pruritus at the application site was diminished in subjects treated with desoximetasone and tacrolimus together compared with tacrolimus alone (P=.04). Combination treatment with desoximetasone and tacrolimus offered increased efficacy and tolerability over tacrolimus alone in patients with atopic dermatitis.
Authors:
Adelaide A Hebert; John Koo; Joseph Fowler; Brian Berman; Carl Rosenberg; Jacob Levitt
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cutis     Volume:  78     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-03-16     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  IM    
Affiliation:
University of Texas Medical School, Houston, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents / administration & dosage*,  adverse effects
Dermatitis, Atopic / drug therapy*
Desoximetasone / administration & dosage*,  adverse effects
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Immunosuppressive Agents / administration & dosage*,  adverse effects
Male
Middle Aged
Ointments
Tacrolimus / administration & dosage*,  adverse effects
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 0/Ointments; 109581-93-3/Tacrolimus; 382-67-2/Desoximetasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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