Document Detail


Desmosterol in human nonalcoholic steatohepatitis.
MedLine Citation:
PMID:  23447451     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Levels of desmosterol in serum and the liver were associated with NASH. These results suggest that serum desmosterol is a marker of disturbed cholesterol metabolism in the liver. Whether desmosterol has a more specific role in the pathophysiology of NASH compared to other cholesterol precursors needs to be investigated.
Authors:
Marko Simonen; Ville Männistö; Joel Leppänen; Dorota Kaminska; Vesa Kärjä; Sari Venesmaa; Pirjo Käkelä; Johanna Kuusisto; Helena Gylling; Markku Laakso; Jussi Pihlajamäki
Publication Detail:
Type:  Comparative Study; Journal Article; Observational Study; Research Support, Non-U.S. Gov't     Date:  2013-07-29
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-02     Completed Date:  2014-02-13     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  976-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alanine Transaminase / metabolism
Biological Markers / metabolism
Biopsy
Cholesterol / metabolism
Cohort Studies
Comorbidity
Desmosterol / metabolism*
Fatty Liver / epidemiology,  metabolism*,  physiopathology
Female
Humans
Liver / metabolism*,  pathology,  physiopathology
Male
Middle Aged
Obesity / epidemiology,  metabolism*,  physiopathology
Chemical
Reg. No./Substance:
0/Biological Markers; 313-04-2/Desmosterol; 97C5T2UQ7J/Cholesterol; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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