Document Detail

Desmopressin therapy for massive hemoptysis associated with severe leptospirosis.
MedLine Citation:
PMID:  12598216     Owner:  NLM     Status:  MEDLINE    
Massive hemoptysis in patients with severe leptospirosis is often resistant to conventional therapies and can rapidly become fatal. Desmopressin is a fast-acting blood-saving agent used in various hereditary and acquired clotting disorders. We used desmopressin infusions to treat massive pulmonary hemorrhage in six leptospirosis patients with respiratory failure, shock, and multiple organ dysfunction. Hemoptysis ceased rapidly in every case, and five patients finally recovered. Two additional patients with less severe hemoptysis were also successfully treated.
Laurent Pea; Laurent Roda; Véronique Boussaud; Bernard Lonjon
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  167     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  726-8     Citation Subset:  AIM; IM    
Critical Care and Clinical Biology Units, Centre Hospitalier Territorial, Papeete, Tahiti.
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MeSH Terms
Deamino Arginine Vasopressin / administration & dosage,  therapeutic use*
Hemoglobins / analysis
Hemoptysis / blood,  drug therapy*,  etiology*
Hemostatics / administration & dosage,  therapeutic use*
Infusions, Parenteral
Multiple Organ Failure / etiology
Platelet Count
Respiration, Artificial
Respiratory Distress Syndrome, Adult / etiology,  therapy
Sodium / blood
Time Factors
Weil Disease / blood,  complications*
Reg. No./Substance:
0/Hemoglobins; 0/Hemostatics; 16679-58-6/Deamino Arginine Vasopressin; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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