| Desmopressin acetate in uncomplicated coronary artery bypass surgery: a prospective randomized clinical trial. | |
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MedLine Citation:
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PMID: 2405964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bleeding in coronary artery bypass procedures increases morbidity and exposes patients to the risks associated with blood transfusion. Desmopressin acetate (DDAVP), a synthetic vasopressin analogue, may limit bleeding during cardiac surgery. In a prospective randomized trial, the authors evaluated the ability of DDAVP to reduce perioperative bleeding during uncomplicated coronary bypass operations. Sixty-two patients who underwent coronary artery bypass grafting were randomized to receive intraoperatively either a placebo or DDAVP. Both groups were similar with respect to operative characteristics and preoperative hematologic profiles, von Willebrand factor levels increased postoperatively in both placebo (2.77 +/- 1.06 versus 2.17 +/- 1.51 U) and DDAVP groups (2.75 +/- 0.94 versus 1.80 +/- 0.88 U). Only the increase in the DDAVP groups was significant (p less than 0.001). There was no difference in total blood loss between the placebo (1826 +/- 849 ml) and DDAVP groups (1716 +/- 688 ml). Total red cell transfusions were similar in placebo (3.4 +/- 1.3 units of blood) and DDAVP groups (3.6 +/- 0.8 units). These results do not support the intraoperative use of DDAVP to reduce perioperative bleeding in routine coronary artery bypass surgery. |
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Authors:
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G S Hedderich; D J Petsikas; B A Cooper; M Leznoff; A J Guerraty; N L Poirier; J F Symes; J E Morin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Canadian journal of surgery. Journal canadien de chirurgie Volume: 33 ISSN: 0008-428X ISO Abbreviation: Can J Surg Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-03-20 Completed Date: 1990-03-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372715 Medline TA: Can J Surg Country: CANADA |
Other Details:
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Languages: eng Pagination: 33-6 Citation Subset: IM |
Affiliation:
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Cardiovascular & Thoracic Surgery Service, Division of Hematology Medical Oncology, Royal Victoria Hospital, McGill University, Montreal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Transfusion Coronary Artery Bypass* Deamino Arginine Vasopressin / therapeutic use* Female Hemorrhage / blood, prevention & control* Humans Male Middle Aged Platelet Count / drug effects Postoperative Complications / prevention & control* Prospective Studies Randomized Controlled Trials as Topic von Willebrand Factor / analysis, drug effects |
| Chemical | |
Reg. No./Substance:
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0/von Willebrand Factor; 16679-58-6/Deamino Arginine Vasopressin |
| Comments/Corrections | |
Comment In:
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Can J Surg. 1990 Feb;33(1):5-6
[PMID:
2302601
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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