Document Detail

Desmopressin acetate in uncomplicated coronary artery bypass surgery: a prospective randomized clinical trial.
MedLine Citation:
PMID:  2405964     Owner:  NLM     Status:  MEDLINE    
Bleeding in coronary artery bypass procedures increases morbidity and exposes patients to the risks associated with blood transfusion. Desmopressin acetate (DDAVP), a synthetic vasopressin analogue, may limit bleeding during cardiac surgery. In a prospective randomized trial, the authors evaluated the ability of DDAVP to reduce perioperative bleeding during uncomplicated coronary bypass operations. Sixty-two patients who underwent coronary artery bypass grafting were randomized to receive intraoperatively either a placebo or DDAVP. Both groups were similar with respect to operative characteristics and preoperative hematologic profiles, von Willebrand factor levels increased postoperatively in both placebo (2.77 +/- 1.06 versus 2.17 +/- 1.51 U) and DDAVP groups (2.75 +/- 0.94 versus 1.80 +/- 0.88 U). Only the increase in the DDAVP groups was significant (p less than 0.001). There was no difference in total blood loss between the placebo (1826 +/- 849 ml) and DDAVP groups (1716 +/- 688 ml). Total red cell transfusions were similar in placebo (3.4 +/- 1.3 units of blood) and DDAVP groups (3.6 +/- 0.8 units). These results do not support the intraoperative use of DDAVP to reduce perioperative bleeding in routine coronary artery bypass surgery.
G S Hedderich; D J Petsikas; B A Cooper; M Leznoff; A J Guerraty; N L Poirier; J F Symes; J E Morin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of surgery. Journal canadien de chirurgie     Volume:  33     ISSN:  0008-428X     ISO Abbreviation:  Can J Surg     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-20     Completed Date:  1990-03-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372715     Medline TA:  Can J Surg     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  33-6     Citation Subset:  IM    
Cardiovascular & Thoracic Surgery Service, Division of Hematology Medical Oncology, Royal Victoria Hospital, McGill University, Montreal.
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MeSH Terms
Blood Transfusion
Coronary Artery Bypass*
Deamino Arginine Vasopressin / therapeutic use*
Hemorrhage / blood,  prevention & control*
Middle Aged
Platelet Count / drug effects
Postoperative Complications / prevention & control*
Prospective Studies
Randomized Controlled Trials as Topic
von Willebrand Factor / analysis,  drug effects
Reg. No./Substance:
0/von Willebrand Factor; 16679-58-6/Deamino Arginine Vasopressin
Comment In:
Can J Surg. 1990 Feb;33(1):5-6   [PMID:  2302601 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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