Document Detail

Desmoplastic infantile astrocytoma with benign histological phenotype and multiple intracranial localizations at presentation.
MedLine Citation:
PMID:  20012157     Owner:  NLM     Status:  MEDLINE    
Desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma (DIG) are rare intracranial tumors that mostly occur in the first 2 years of life and involve superficial cerebral cortex. Despite the large size of these lesions and some worrisome histological and radiological features, prognosis is generally favorable after gross total resection. We report an original observation of a desmoplastic infantile astrocytoma in a 5-year-old boy with multiple localizations on initial presentation, including the unusual subtentorial region. Magnetic resonance imaging showed a temporal tumor with prepontine and interpeduncular extension, and two other distinct localizations in cisterna magna and left cerebellar hemisphere. Leptomeningeal enhancements were present around the basal cistern. The surgical samples, corresponding exclusively to subtentorial lesions, were devoid of anaplastic features; the temporal lesion was untouched because of the interpeduncular extension. Adjuvant chemotherapy was applied, with shrinkage of lesions. DIA and DIG are more generally unifocal at initial presentation. When the tumor is large, multilobular involvement is common, but multiple location of DIG is, on the contrary, very rare. Previously, only five cases of DIG/DIA located in two or more separate locations have been published. We report the sixth, and first noninfantile, case of DIA/DIG with multifocal initial presentation.
E Uro-Coste; G Ssi-Yan-Kai; C Guilbeau-Frugier; S Boetto; A I Bertozzi; A Sevely; K Lolmede; M B Delisle
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-12-11
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  98     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
Department of Pathology, Rangueil University Hospital, Toulouse, France.
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MeSH Terms
Astrocytoma / pathology*,  radiography
Brain / pathology,  radiography
Brain Neoplasms / pathology*,  radiography
Child, Preschool
Magnetic Resonance Imaging / methods
Tomography Scanners, X-Ray Computed

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