| Desmoplastic fibroma with malignant transformation. | |
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MedLine Citation:
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PMID: 20123458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Desmoplastic fibroma (DF) is a rare neoplasm of bone, showing infiltrative and locally aggressive nature. Here, we report a case of DF with an unusual histology arising in a 41-year-old female in the left distal femur, which was detected by plain x-ray as an osteolytic lesion and by magnetic resonance imaging as a well-demarcated mass with endosteal scalloping. Pathologically, the tumor was composed mainly of bland-looking spindle cells in abundant collagenous stroma, accompanied with areas of myxofibrosarcomatous and malignant fibrous histiocytomatous components. These histologically different areas were admixed with each other. The array-based comparative genomic hybridization study on the histologically different areas showed some specific gained or lost loci according to their histologic features. The specific genetic events and the histologic features of this case might represent the malignant transformation of DF. |
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Authors:
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Hye Sook Min; Hyun Gyui Kang; Joo-Hyuk Lee; Geon Kook Lee; Jae Y Ro |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-06-21 |
Journal Detail:
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Title: Annals of diagnostic pathology Volume: 14 ISSN: 1532-8198 ISO Abbreviation: Ann Diagn Pathol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800503 Medline TA: Ann Diagn Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 50-5 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pathology, National Cancer Center, Goyang, Gyoung-Gi, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Neoplasms / genetics, pathology*, radiography Cell Dedifferentiation Cell Transformation, Neoplastic / genetics, pathology* Comparative Genomic Hybridization Female Femur / pathology*, radiography Fibroma, Desmoplastic / genetics, pathology*, radiography Humans |
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