Document Detail


Desmoplasia in medullary thyroid carcinoma: a reliable indicator of metastatic potential.
MedLine Citation:
PMID:  18370959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To evaluate the reliability of desmoplasia as a reproducible morphological parameter indicating the metastatic potential of medullary thyroid carcinoma (MTC). METHODS AND RESULTS: One hundred and twenty cases of MTC of the Medical University of Vienna, Austria and 76 cases from the School of Medicine of Marseille, France were analysed for the presence of desmoplastic stroma reaction by four endocrine pathologists. Intra- and interobserver concordance was assessed. The Austrian cases were also analysed for various morphological parameters. Intra- and interobserver concordance were highly significant with a kappa value of 0.883 for intra-observer reliability and 0.837, 0.79 and 0.758, respectively, when pathologists N.N., C.D.M. and K.W.S. reviewed the Austrian cases. The cases from France were reviewed by C.D.M. and K.K. with a kappa value of 0.759. None of the cases that were categorized as desmoplasia negative by any of the investigators showed lymph node metastasis. No other distinct morphological characteristics could be assigned to the MTCs without desmoplasia. CONCLUSIONS: Our data indicate desmoplasia to be a reliable and highly reproducible parameter with regard to lymph node metastatic potential.
Authors:
O Koperek; C Scheuba; M Cherenko; N Neuhold; C De Micco; K W Schmid; B Niederle; K Kaserer
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  52     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-04-17     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  623-30     Citation Subset:  IM    
Affiliation:
Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Medullary / diagnosis*,  metabolism,  secondary
Collagen
Female
Fibrosis
Humans
Immunohistochemistry
Lymph Nodes / pathology
Lymphatic Metastasis / diagnosis
Male
Middle Aged
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Stromal Cells / metabolism,  pathology
Thyroid Neoplasms / diagnosis*,  metabolism
Chemical
Reg. No./Substance:
9007-34-5/Collagen
Comments/Corrections
Comment In:
Histopathology. 2008 Oct;53(4):481; author reply 482-3   [PMID:  18764881 ]

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