| Desmin modulates lung elastic recoil and airway responsiveness. | |
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MedLine Citation:
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PMID: 16387753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Desmin is a structural protein that is expressed in smooth muscle cells of both airways and alveolar ducts. Therefore, desmin could be well situated to participate in passive and contractile force transmission in the lung. We hypothesized that desmin modulates lung compliance, lung recoil pressure, and airway contractile response. To test this hypothesis, respiratory system complex impedance (Zin,rs) at different positive end-expiratory pressure (PEEP) levels and quasi-static pressure-volume data were obtained in desmin-null and wild-type mice at baseline and during methacholine administration. Airways and lung tissue properties were partitioned by fitting Zin,rs to a constant-phase model. Relative to controls, desmin-null mice showed 1) lower values for lung stiffness and recoil pressure at baseline and induced airway constriction, 2) greater negative PEEP dependence of H and airway resistance under baseline conditions and cholinergic stimulation, and 3) airway hyporesponsiveness. These results demonstrate that desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response. |
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Authors:
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Felix R Shardonofsky; Yassemi Capetanaki; Aladin M Boriek |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2005-12-30 |
Journal Detail:
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Title: American journal of physiology. Lung cellular and molecular physiology Volume: 290 ISSN: 1040-0605 ISO Abbreviation: Am. J. Physiol. Lung Cell Mol. Physiol. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-10 Completed Date: 2006-06-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901229 Medline TA: Am J Physiol Lung Cell Mol Physiol Country: United States |
Other Details:
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Languages: eng Pagination: L890-6 Citation Subset: IM |
Affiliation:
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University of Texas Southwestern Medical Center, Department of Pediatrics, 5323 Harry Hines Blvd., Dallas, TX 75390-9063, USA. felix.shardonofsky@utsouthwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance
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physiology* Animals Desmin / deficiency, genetics, physiology* Elasticity Lung / physiology* Lung Compliance / drug effects, physiology Mice Mice, Knockout Positive-Pressure Respiration Respiratory Mechanics / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL 02839/HL/NHLBI NIH HHS; HL 63134/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Desmin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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