Document Detail

Desmin modulates lung elastic recoil and airway responsiveness.
MedLine Citation:
PMID:  16387753     Owner:  NLM     Status:  MEDLINE    
Desmin is a structural protein that is expressed in smooth muscle cells of both airways and alveolar ducts. Therefore, desmin could be well situated to participate in passive and contractile force transmission in the lung. We hypothesized that desmin modulates lung compliance, lung recoil pressure, and airway contractile response. To test this hypothesis, respiratory system complex impedance (Zin,rs) at different positive end-expiratory pressure (PEEP) levels and quasi-static pressure-volume data were obtained in desmin-null and wild-type mice at baseline and during methacholine administration. Airways and lung tissue properties were partitioned by fitting Zin,rs to a constant-phase model. Relative to controls, desmin-null mice showed 1) lower values for lung stiffness and recoil pressure at baseline and induced airway constriction, 2) greater negative PEEP dependence of H and airway resistance under baseline conditions and cholinergic stimulation, and 3) airway hyporesponsiveness. These results demonstrate that desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.
Felix R Shardonofsky; Yassemi Capetanaki; Aladin M Boriek
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2005-12-30
Journal Detail:
Title:  American journal of physiology. Lung cellular and molecular physiology     Volume:  290     ISSN:  1040-0605     ISO Abbreviation:  Am. J. Physiol. Lung Cell Mol. Physiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901229     Medline TA:  Am J Physiol Lung Cell Mol Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  L890-6     Citation Subset:  IM    
University of Texas Southwestern Medical Center, Department of Pediatrics, 5323 Harry Hines Blvd., Dallas, TX 75390-9063, USA.
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MeSH Terms
Airway Resistance / physiology*
Desmin / deficiency,  genetics,  physiology*
Lung / physiology*
Lung Compliance / drug effects,  physiology
Mice, Knockout
Positive-Pressure Respiration
Respiratory Mechanics / drug effects,  physiology
Grant Support
Reg. No./Substance:

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