Document Detail


Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response.
MedLine Citation:
PMID:  15804873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prognostic importance of baseline urines for cocaine was examined in a randomized, placebo-controlled, twelve-week clinical trial in 165 opioid- and cocaine-dependent patients who were treated with desipramine (DMI) in combination with buprenorphine (BUP) or methadone (Meth). Patients with a cocaine-positive urine at baseline (CU+) had significantly fewer cocaine-free urines than those with a negative urine at baseline (CU-neg). The CU+ patients showed a treatment effect of DMI. This DMI effect was significant in patients maintained on BUP but not on Meth.
Authors:
Thomas Kosten; Mehmet Sofuoglu; James Poling; Kishor Gonsai; Alison Oliveto
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions     Volume:  14     ISSN:  1055-0496     ISO Abbreviation:  Am J Addict     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-04-04     Completed Date:  2005-06-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9208821     Medline TA:  Am J Addict     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-17     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA. Thomas.Kosten@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Uptake Inhibitors / therapeutic use*
Adult
Buprenorphine / therapeutic use
Cocaine / urine*
Cocaine-Related Disorders / drug therapy*,  rehabilitation*
Desipramine / therapeutic use*
Dopamine Uptake Inhibitors / urine*
Female
Humans
Male
Methadone / therapeutic use
Middle Aged
Narcotic Antagonists / therapeutic use
Placebos
Predictive Value of Tests
Prognosis
Treatment Outcome
Urinalysis
Grant Support
ID/Acronym/Agency:
K05-DA 0454/DA/NIDA NIH HHS; P50-09250//PHS HHS; R01-DA05626/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Dopamine Uptake Inhibitors; 0/Narcotic Antagonists; 0/Placebos; 50-36-2/Cocaine; 50-47-5/Desipramine; 52485-79-7/Buprenorphine; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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