Document Detail

Desipramine-induced down regulation of beta-adrenergic receptors: effects of noradrenergic and serotonergic neuronal activities and of alpha 2-adrenergic receptor mediated mechanisms
MedLine Citation:
PMID:  3038720     Owner:  NLM     Status:  MEDLINE    
The mechanisms of antidepressant (desipramine)-induced down regulation of beta-adrenergic receptors were investigated. The number of beta-adrenergic receptors in rat cerebral cortex was increased by the destruction of norepinephrine (NE) neurons with 6-hydroxydopamine or DSP-4 pretreatments. Desipramine (DMI)-induced down regulation of beta-receptors was completely prevented by these procedures, whereas the destruction of serotonin (5-HT) neurons neither changed the receptor number nor prevented the DMI-induced down regulation. The number of beta-adrenergic receptors showed a decrease within 3 days by treatment of DMI plus (+) mianserin or yohimbine which promotes NE and 5-HT release from nerve endings through presynaptic alpha 2-adrenergic antagonism. Another alpha 2-adrenergic antagonist (-)mianserin, which promotes only 5-HT release, also accelerated the down regulation induced by DMI, but this acceleration was not prevented by the destruction of 5-HT neurons. Combination of DMI with 5-HT releasing agent methiothepin (5-HT autoreceptor antagonist) did not accelerate beta-receptor down regulation. These results suggest that 1) NE availability in the synaptic cleft plays a significant role in the regulation of beta-receptor number, but 2) postsynaptic alpha 2-adrenergic mechanisms also seem to contribute to the regulation, whereas 3) 5-HT neurons have no significant effect on the process.
S Matsubara
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  [Hokkaido igaku zasshi] The Hokkaido journal of medical science     Volume:  62     ISSN:  0367-6102     ISO Abbreviation:  Hokkaido Igaku Zasshi     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-09-03     Completed Date:  1987-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  17410290R     Medline TA:  Hokkaido Igaku Zasshi     Country:  JAPAN    
Other Details:
Languages:  jpn     Pagination:  301-10     Citation Subset:  IM    
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MeSH Terms
Antidepressive Agents / pharmacology*
Brain / metabolism
Desipramine / pharmacology*
Neurons / physiology
Norepinephrine / physiology*
Rats, Inbred Strains
Receptors, Adrenergic, alpha / physiology
Receptors, Adrenergic, beta / drug effects*
Serotonin / physiology*
Reg. No./Substance:
0/Antidepressive Agents; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 50-47-5/Desipramine; 50-67-9/Serotonin; 51-41-2/Norepinephrine

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