Document Detail


Designed cyclopentenone prostaglandin derivatives as neurite outgrowth-promoting compounds for CAD cells, a rat catecholaminergic neuronal cell line of the central nervous system.
MedLine Citation:
PMID:  10984633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here we reported the effects of neurite outgrowth-promoting prostaglandins (NEPP's) on neurons of the central nervous system (CNS). Serum deprivation promoted neurite outgrowth from CAD cells, a CNS-derived cathecholaminergic neuronal cell line. NEPP's (0.05-0.2 microM) accelerated the neurite outgrowth from CAD cells in serum-free medium but didn't in serum-containing medium. Through the study of structure-function relationship with the NEPP's 1-10, NEPP 10 (13,14-dihydro-15-epi-Delta(7)-prostaglandin A(1) (methyl ester) revealed the best compound, exhibiting potent neurite outgrowth-promoting activity with minimal cytotoxicity, suggesting that it is the best compound for drug development.
Authors:
T Satoh; K Furuta; K Tomokiyo; M Suzuki; Y Watanabe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  291     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-12     Completed Date:  2000-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  167-70     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, Osaka Bioscience Institute, Suita-shi, 565-0874, Osaka, Japan. tsatoh@obi.or.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / drug effects
Cell Line
Cell Survival / drug effects
Cyclopentanes / chemistry*
Dose-Response Relationship, Drug
Drug Design
Neurites / drug effects*
Neurons / cytology,  drug effects*,  metabolism
Prostaglandins A / chemistry,  pharmacology*
Rats
Structure-Activity Relationship
Tetrazolium Salts
Thiazoles
Chemical
Reg. No./Substance:
0/13,14-dihydro-delta7-prostaglandin A1 methyl ester; 0/Cyclopentanes; 0/Prostaglandins A; 0/Tetrazolium Salts; 0/Thiazoles; 298-93-1/thiazolyl blue; 930-30-3/cyclopentenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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