| Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists. | |
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MedLine Citation:
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PMID: 17157019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model. |
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Authors:
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Hee Oon Han; Seung Hae Kim; Kyoung-Hee Kim; Gwong-Cheung Hur; Hyeon Joo Yim; Hee-Kyung Chung; Sung Ho Woo; Ki Dong Koo; Chang-Seok Lee; Jong Sung Koh; Geun Tae Kim |
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Publication Detail:
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Type: Journal Article Date: 2006-11-18 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 17 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 937-41 Citation Subset: IM |
Affiliation:
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Research and Development, LG Life Sciences, 104-1 Munji-dong, Yuseong-gu, Daejon 305-380, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Area Under Curve Biological Availability Blood Glucose / metabolism Cell Line, Tumor Drug Design Humans Hypoglycemic Agents / chemical synthesis*, pharmacokinetics, pharmacology* Indicators and Reagents Lipids / blood Magnetic Resonance Spectroscopy Mass Spectrometry Mice Models, Molecular PPAR alpha / agonists* PPAR gamma / agonists* Phenylpropionates / chemical synthesis*, pharmacology* Structure-Activity Relationship Thiazolidinediones / pharmacology Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Indicators and Reagents; 0/Lipids; 0/PPAR alpha; 0/PPAR gamma; 0/Phenylpropionates; 0/Thiazolidinediones; 0/Triglycerides; 122320-73-4/rosiglitazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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