| Design and synthesis of novel threosyl-5'- deoxyphosphonic Acid purine analogues as potent anti-hiv agents. | |
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MedLine Citation:
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PMID: 22497256 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The discovery of threosyl phosphonate nucleoside (PMDTA, EC(50) = 2.53 μM) as a potent anti-HIV agent has led to the synthesis and biological evaluation of 5 '-deoxyversions of threosyl phosphonate nucleosides from 1,4-dihydroxy-2-butene. The synthesized nucleoside phosphonic acid analogues 14 and 19 were tested for anti-HIV activity as well as cytotoxicity. The adenine analogue 14 exhibits moderate in vitro anti-HIV-1 activity (EC(50) = 12.6 μM). |
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Authors:
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Lian Jin Liu; Eunae Kim; Joon Hee Hong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 31 ISSN: 1532-2335 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 411-22 Citation Subset: IM |
Affiliation:
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a BK-21 Project Team , College of Pharmacy, Chosun University , Kwangju , Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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