Document Detail

Design and synthesis of novel threosyl-5'- deoxyphosphonic Acid purine analogues as potent anti-hiv agents.
MedLine Citation:
PMID:  22497256     Owner:  NLM     Status:  In-Data-Review    
The discovery of threosyl phosphonate nucleoside (PMDTA, EC(50) = 2.53 μM) as a potent anti-HIV agent has led to the synthesis and biological evaluation of 5 '-deoxyversions of threosyl phosphonate nucleosides from 1,4-dihydroxy-2-butene. The synthesized nucleoside phosphonic acid analogues 14 and 19 were tested for anti-HIV activity as well as cytotoxicity. The adenine analogue 14 exhibits moderate in vitro anti-HIV-1 activity (EC(50) = 12.6 μM).
Lian Jin Liu; Eunae Kim; Joon Hee Hong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  31     ISSN:  1532-2335     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-22     Citation Subset:  IM    
a BK-21 Project Team , College of Pharmacy, Chosun University , Kwangju , Republic of Korea.
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