Document Detail


Design and synthesis of novel threosyl-5'- deoxyphosphonic Acid purine analogues as potent anti-hiv agents.
MedLine Citation:
PMID:  22497256     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The discovery of threosyl phosphonate nucleoside (PMDTA, EC(50) = 2.53 μM) as a potent anti-HIV agent has led to the synthesis and biological evaluation of 5 '-deoxyversions of threosyl phosphonate nucleosides from 1,4-dihydroxy-2-butene. The synthesized nucleoside phosphonic acid analogues 14 and 19 were tested for anti-HIV activity as well as cytotoxicity. The adenine analogue 14 exhibits moderate in vitro anti-HIV-1 activity (EC(50) = 12.6 μM).
Authors:
Lian Jin Liu; Eunae Kim; Joon Hee Hong
Related Documents :
22337296 - Molecular epidemiology of hepatitis a virus in patients in the ahwaz region of iran.
22912636 - Controlling the hiv/aids epidemic: current status and global challenges.
9220386 - A single tube two compartment reverse transcription polymerase chain reaction system fo...
22320006 - Sub-saharan african randomised clinical trials into male circumcision and hiv transmiss...
3348026 - Heterosexual and perinatal transmission of human immunodeficiency virus in a low preval...
20337926 - Flexible and individualized treatment to achieve sustained viral response for recurrent...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  31     ISSN:  1532-2335     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-22     Citation Subset:  IM    
Affiliation:
a BK-21 Project Team , College of Pharmacy, Chosun University , Kwangju , Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genotyping of -374A/T, -429A/G, And 63 bp Ins/Del Polymorphisms of Rage By Rapid One-Step Hexaprimer...
Next Document:  An improved protection-free one-pot chemical synthesis of 2'-deoxynucleoside-5'-triphosphates.