| Design and synthesis of novel nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors from caffeic acid phenethyl ester. | |
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MedLine Citation:
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PMID: 19625188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of nitrogen-containing polyhydroxylated aromatics from caffeic acid phenethyl ester were designed and synthesized as HIV-1 integrase inhibitors. Most of these compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in the 3'-end processing and the strand transfer. Their key structure-activity relationship was also discussed. |
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Authors:
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Peng Wang; Chuan Liu; Tino Sanches; Yuan Zhong; Bo Liu; Junlong Xiong; Nouri Neamati; Guisen Zhao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-03 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 19 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-29 Completed Date: 2009-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4574-8 Citation Subset: IM |
Affiliation:
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School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong Province 250012, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Caffeic Acids
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chemistry* Drug Design HIV Integrase / chemistry*, metabolism HIV Integrase Inhibitors / chemical synthesis*, chemistry, pharmacology Humans Nitrogen / chemistry Phenylethyl Alcohol / analogs & derivatives*, chemistry Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Caffeic Acids; 0/HIV Integrase Inhibitors; 0/p31 integrase protein, Human immunodeficiency virus 1; 104594-70-9/caffeic acid phenethyl ester; 60-12-8/Phenylethyl Alcohol; 7727-37-9/Nitrogen; EC 2.7.7.-/HIV Integrase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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