| Design and synthesis of novel 1',3'-dioxolane 5'-deoxyphosphonic Acid purine analogues as potent antiviral agents. | |
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MedLine Citation:
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PMID: 22303989 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Electronic parameters of 1',3 '-oxygen play significant roles in steering the conformation of nucleoside phosphonic acid analogues. To investigate the relationship of two oxygen atoms with antiviral enhancement, novel 1',3 '-dioxolane 5 '-deoxyphosphonic acid purine analogues were synthesized via de novo acyclic stereoselective route from acrolein and glycolic acid. The synthesized nucleoside phosphonic acid analogues 14 and 19 were subjected to antiviral screening against several viruses, such as HIV-1, HSV-1, HSV-2, and HCMV. The guanine analogue 19 exhibits in vitro anti-HIV-1 activity similar to that of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) in MT-4 cells. |
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Authors:
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Eunae Kim; Lian Jin Liu; Wonjae Lee; Joon Hee Hong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 31 ISSN: 1532-2335 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 85-96 Citation Subset: IM |
Affiliation:
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a College of Pharmacy , Chosun University , Kwangju , Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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