Document Detail

Design, synthesis and evaluations of acridone derivatives using Candida albicans--search for MDR modulators led to the identification of an anti-candidiasis agent.
MedLine Citation:
PMID:  19409796     Owner:  NLM     Status:  MEDLINE    
In order to search for MDR modulators, rationally designed acridone derivatives were investigated for their effect on influx or efflux of Rhodamine6G (R6G) in CAI4 cells. Results of these investigations indicate that in presence of compound 12, inhibition of growth of CAI4 cells and also an increased influx/efflux of R6G in CAI4 cells have been observed. This seems to be occurring due to the cell wall rupturing of Candida albicans. Compound 12 may be a suitable candidate for candidiasis therapy.
Palwinder Singh; Jatinder Kaur; Bhawna Yadav; Sneha Sudha Komath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-18
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  17     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-19     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3973-9     Citation Subset:  IM    
Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
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MeSH Terms
Acridines / chemical synthesis,  chemistry*,  pharmacology
Antifungal Agents* / chemical synthesis,  chemistry,  pharmacology
Candida albicans / drug effects*
Drug Design*
Drug Resistance, Multiple, Fungal*
Microbial Sensitivity Tests
Molecular Structure
Piperidines / chemical synthesis,  chemistry,  pharmacology
Reg. No./Substance:
0/Acridines; 0/Antifungal Agents; 0/Piperidines; 578-95-0/acridone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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