| Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors. | |
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MedLine Citation:
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PMID: 18830166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active site. |
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Authors:
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Mario Sechi; Ugo Azzena; Maria Paola Delussu; Roberto Dallocchio; Alessandro Dessì; Alessia Cosseddu; Nicolino Pala; Nouri Neamati |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-01 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 13 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-02 Completed Date: 2008-12-10 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 2442-61 Citation Subset: IM |
Affiliation:
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Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy. mario.sechi@uniss.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amides Anti-HIV Agents / chemical synthesis, chemistry, pharmacology Azides Catalytic Domain Computer Simulation Drug Design HIV Integrase Inhibitors / chemistry*, pharmacology Humans Malonates / chemical synthesis*, chemistry, pharmacology* Protein Binding Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Anti-HIV Agents; 0/Azides; 0/HIV Integrase Inhibitors; 0/Malonates; 141-82-2/malonic acid |
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