| Design, synthesis, and biological evaluation of 4-(5-dimethylamino-naphthalene-1-sulfon-amido)-3-(4-iodophenyl)butanoic acid as a novel molecular probe for apoptosis imaging. | |
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MedLine Citation:
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PMID: 20599754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apoptosis (programmed cell death) plays a crucial role in the pathogenesis of many disorders, thus the detection of apoptotic cells can provide the physician with important information to further therapeutic strategies and would substantially advance patient care. A small molecule, 4-(5-dimethylamino-naphthalene-1-sulfonamido)-3-(4-iodo-phenyl)butanoic acid (DNSBA), was designed as a novel probe for imaging apoptosis and synthesized with good yield. The biological characterization demonstrated that DNSBA can be used to specifically and selectively detect apoptotic cancer cells at all stages. DNSBA is also designed as a potential SPECT and PET probe when labeled with radioiodine (I-123, -124, and -131). |
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Authors:
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Wenbin Zeng; Weimin Miao; Michael Le Puil; Guangqing Shi; John Biggerstaff; George W Kabalka; David Townsend |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-01 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 398 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 571-5 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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School of Pharmaceutical Sciences, Central South University, 172 Tongzipo Road, Changsha 410078, China. wbzeng@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis* Cell Line, Tumor Dansyl Compounds / chemical synthesis, chemistry* Fluorescent Dyes / chemical synthesis, chemistry* Humans Neoplasms / pathology* Phenylpropionates / chemical synthesis, chemistry* Positron-Emission Tomography / methods |
| Chemical | |
Reg. No./Substance:
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0/4-(5-dimethylaminonaphthalene-1-sulfonamido)-3-(4-iodophenyl)butanoic acid; 0/Dansyl Compounds; 0/Fluorescent Dyes; 0/Phenylpropionates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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