| Design and synthesis of N-(pyridylacryl) amino acid derivatives as potential radiosensitizers against HeLa-S3 cells in vitro. | |
| | |
MedLine Citation:
|
PMID: 7687084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A new series of N-(pyridylacryl) amino acid derivatives have been designed and synthesized as potential radiosensitizers in an effort to increase therapeutic efficacy with less toxicity. Radiosensitization and cytotoxicity of the newly synthesized compounds upon HeLa-S3 cells were measured. The main effects of the reduction of the shoulder width and Do value of the survival curve by 3-pyridylacrylsarcosine (3A) and 4-pyridylacrylsarcosine (4A) were observed. This work has demonstrated that this series of compounds, especially 3A and 4A, or their structurally related compounds, showed great clinical potential as radiosensitizers if significant radiosensitizing activity in vivo could be achieved. |
| | |
Authors:
|
J Xin; B Hu; Z Li; F S Mi; Y Shen |
Related Documents
:
|
15963694 - Synergistic effect of antibacterial agents human beta-defensins, cathelicidin ll-37 and... 10834274 - Synthesis and antitumor activities of amino acid prodrugs of amino-combretastatins. 1243074 - Hypolipemic activity of clofibrate-related compounds. 21612664 - New methods to measure residues coevolution in proteins. 9421414 - Glucagon-like peptide-1-(7-36) amide and peptide yy mediate intraduodenal fat-induced i... 12640744 - Odontoblast function seen as the response of dentinal tissue to dental caries. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Yao xue xue bao = Acta pharmaceutica Sinica Volume: 28 ISSN: 0513-4870 ISO Abbreviation: Yao Xue Xue Bao Publication Date: 1993 |
Date Detail:
|
Created Date: 1993-08-11 Completed Date: 1993-08-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 21710340R Medline TA: Yao Xue Xue Bao Country: CHINA |
Other Details:
|
Languages: eng Pagination: 97-104 Citation Subset: IM |
Affiliation:
|
Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Hela Cells Humans Pyridines / chemical synthesis*, chemistry, pharmacology Radiation-Sensitizing Agents / chemical synthesis*, chemistry, pharmacology Sarcosine / analogs & derivatives*, chemical synthesis, chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Pyridines; 0/Radiation-Sensitizing Agents; 107-97-1/Sarcosine; 148332-68-7/4-pyridylacrylsarcosine; 148332-70-1/3-pyridylacrylsarcosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thrombophlebitis--basic principles of treatment
Next Document: Immunohistochemical staining for glial fibrillary acidic protein (GFAP) after deafferentation or isc...