Document Detail


Design of a study to evaluate drug therapy of serious ventricular rhythm disturbances after an acute myocardial infarction.
MedLine Citation:
PMID:  338307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A study was designed to investigate whether long-term use of aprindine can prevent sudden death from primary ventricular fibrillation. Patients with a proven recent myocardial infarction and malignant ventricular arrhythmias occurring late after the acute episode were asked to participate in a 1-yr, double-blind, randomized, placebo-controlled trial to suppress the rhythm disturbances observed on an ambulatory electrocardiogram. Particular care was taken to monitor drug adherence. Arrhythmia detection by ambulatory electrocardiography was used to assess drug efficacy; side-effects establish the maximum tollerated dose for each individual patient. Aprindine was therefore used under optimal circumstances. An interactive computer system served as a data base and provided the investigators and the monitoring committee with all the information required for a proper evaluation of the progress of the study.
Authors:
F Hagemeijer; B Glaser; J P van Durme; M Bogaert
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of cardiology     Volume:  6     ISSN:  0301-4711     ISO Abbreviation:  Eur J Cardiol     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404054     Medline TA:  Eur J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  299-310     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aprindine / administration & dosage,  therapeutic use*
Clinical Trials as Topic
Computers
Death, Sudden*
Follow-Up Studies
Humans
Indenes / therapeutic use*
Informed Consent
Myocardial Infarction / complications*
Placebos
Research Design*
Ventricular Fibrillation / drug therapy*,  etiology
Chemical
Reg. No./Substance:
0/Indenes; 0/Placebos; 37640-71-4/Aprindine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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