Document Detail


Design of second generation therapeutic recombinant bone morphogenetic proteins.
MedLine Citation:
PMID:  19910235     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF beta super family. To date, more than twenty human BMPs have been identified. Of these, BMP-2 and BMP-7 (also known as osteogenic protein 1 or OP-1) are the only BMPs used clinically. Recombinant forms of both proteins are currently being implanted surgically to induce spinal fusion and to treat long bone non-union fractures. However, in both indications, large quantities of recombinant proteins are needed to induce new bone formation. This translates to higher costs and potential safety risks. Various genetic engineering approaches are being considered to produce second generation BMPs with improved safety and efficacy profiles. Modified BMPs with one or more of the following characteristics are being considered: (i) improved binding affinity to specific target cell surface BMP receptors, (ii) decreased sensitivity to natural BMP inhibitors, (iii) better immunogenicity profile, and (iv) increased solubility and stability, to cite a few. This review summarizes the progress made so far in this field and gives a perspective on what the next generation BMPs could look like.
Authors:
Moulay Hicham Alaoui-Ismaili; Dean Falb
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Publication Detail:
Type:  Journal Article     Date:  2009-11-11
Journal Detail:
Title:  Cytokine & growth factor reviews     Volume:  20     ISSN:  1879-0305     ISO Abbreviation:  Cytokine Growth Factor Rev.     Publication Date:    2009 Oct-Dec
Date Detail:
Created Date:  2009-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612306     Medline TA:  Cytokine Growth Factor Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-7     Citation Subset:  IM    
Affiliation:
Stryker Biotech, Hopkinton, MA 01748, USA. Hicham.alaoui@stryker.com
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