Document Detail


Design and properties of novel self-curing acrylic formulations for application in intervertebral disks restoration.
MedLine Citation:
PMID:  16004445     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Novel acrylic formulations incorporating an amphiphilic macromonomer, Triton methacrylate MT, have been prepared to be applied in intervertebral disks (IVD) restoration processes. The solid phase of the formulations is composed of poly (methyl methacrylate), PMMA, incorporating in some cases chondroitin sulfate, CS, as a regenerative bioactive molecule, whereas the liquid phase is constituted by MT and 2-hydroxyethyl methacrylate, HEMA, and in some formulations acrylic acid, AA, was also added. These are prepared similarly to acrylic bone cement formulations. The obtained curing parameters, with maximum temperatures in the range of 41-72 degrees C, make them suitable to be applied as injectable systems. Glass transition temperatures and swelling degree have also been determined. Mechanical properties such as compressive, stress relaxation, and shear tests have been analyzed for all of the prepared IVD formulations exhibiting shape memory characteristics and a pronounced elastic behavior that make them as excellent candidates for the intervertebral application.
Authors:
Elena Larraz; Carlos Elvira; Julio San Román
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomacromolecules     Volume:  6     ISSN:  1525-7797     ISO Abbreviation:  Biomacromolecules     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-07-11     Completed Date:  2005-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2058-66     Citation Subset:  IM    
Affiliation:
Institute of Polymer Science and Technology, CSIC, c/Juan de la Cierva 3, 28006 Madrid, Spain. ictl348@ictp.csic.es
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MeSH Terms
Descriptor/Qualifier:
Acrylates / chemistry*
Biocompatible Materials*
Elasticity
Intervertebral Disk*
Materials Testing
Viscosity
Chemical
Reg. No./Substance:
0/Acrylates; 0/Biocompatible Materials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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