| Design of polymeric nanoparticles for biomedical delivery applications. | |
| | |
MedLine Citation:
|
PMID: 22334259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Polymeric nanoparticles-based therapeutics show great promise in the treatment of a wide range of diseases, due to the flexibility in which their structures can be modified, with intricate definition over their compositions, structures and properties. Advances in polymerization chemistries and the application of reactive, efficient and orthogonal chemical modification reactions have enabled the engineering of multifunctional polymeric nanoparticles with precise control over the architectures of the individual polymer components, to direct their assembly and subsequent transformations into nanoparticles of selective overall shapes, sizes, internal morphologies, external surface charges and functionalizations. In addition, incorporation of certain functionalities can modulate the responsiveness of these nanostructures to specific stimuli through the use of remote activation. Furthermore, they can be equipped with smart components to allow their delivery beyond certain biological barriers, such as skin, mucus, blood, extracellular matrix, cellular and subcellular organelles. This tutorial review highlights the importance of well-defined chemistries, with detailed ties to specific biological hurdles and opportunities, in the design of nanostructures for various biomedical delivery applications. |
| | |
Authors:
|
Mahmoud Elsabahy; Karen L Wooley |
Related Documents
:
|
7462899 - The influence of naturally and artificially elevated levels of sodium in drinking water... 22803509 - Regulatory focus surface water models fail to predict insecticide concentrations in the... 20924919 - Arsenic in drinking water wells on the bolivian high plain: field monitoring and effect... 22868949 - Colloidal nanoparticle clusters: functional materials by design. 21240559 - Highly-compliant, microcable neuroelectrodes fabricated from thin-film gold and pdms. 6111489 - Compulsive water drinking in pregnancy. 22109629 - Water restriction and fluid temperature alter preference for water and sucrose solutions. 3982019 - Skin wound healing determined by water loss. 23621379 - Polysaccharide-hair cationic polypeptide nanogels: self-assembly and enzymatic polymeri... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-02-14 |
Journal Detail:
|
Title: Chemical Society reviews Volume: 41 ISSN: 1460-4744 ISO Abbreviation: Chem Soc Rev Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-03-12 Completed Date: 2012-07-02 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 0335405 Medline TA: Chem Soc Rev Country: England |
Other Details:
|
Languages: eng Pagination: 2545-61 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, USA. mahmoud.elsabahy@chem.tamu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Drug Delivery Systems* Drug Design* Humans Nanoparticles / chemistry* Polymers / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
|
HHSN268201000046C/HL/NHLBI NIH HHS; HHSN268201000046C//PHS HHS; R01 DK082546/DK/NIDDK NIH HHS; R01 DK082546-03/DK/NIDDK NIH HHS; R01-DK082546/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Polymers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: "The more pain I have, the more I want to eat": Obesity in the context of chronic pain.
Next Document: Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolero...