Document Detail


Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.
MedLine Citation:
PMID:  23416453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of a novel pharmacophore comprising a DNA-targeted platinum-acridine hybrid agent and estrogen receptor-targeted 4-hydroxy-N-desmethyltamoxifen (endoxifen) using carbamate coupling chemistry and its evaluation in breast cancer cell lines are described.
Authors:
Song Ding; Xin Qiao; Gregory L Kucera; Ulrich Bierbach
Related Documents :
23771733 - Metalloproteinase-disintegrin adam12 is associated with a breast tumor-initiating cell ...
23896523 - Monitoring proliferative activities of hormone-like odorants in human breast cancer cel...
10458833 - Myiasis secondary to sermatobia hominis (human botfly) presenting as a long-standing br...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-23     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  2415-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acridines / chemistry*
Antineoplastic Agents, Hormonal / chemistry*,  therapeutic use,  toxicity
Breast Neoplasms / drug therapy
Cell Line, Tumor
Cell Survival / drug effects
DNA / chemistry,  metabolism
Drug Design*
Female
Humans
Intercalating Agents / chemistry,  therapeutic use,  toxicity
MCF-7 Cells
Platinum / chemistry*
Receptors, Estrogen / antagonists & inhibitors,  metabolism
Tamoxifen / analogs & derivatives*,  chemistry
Grant Support
ID/Acronym/Agency:
CA101880/CA/NCI NIH HHS; P30 CA012197/CA/NCI NIH HHS; R01 CA101880/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Acridines; 0/Antineoplastic Agents, Hormonal; 0/Intercalating Agents; 0/Receptors, Estrogen; 094ZI81Y45/Tamoxifen; 110025-28-0/4-hydroxy-N-desmethyltamoxifen; 49DFR088MY/Platinum; 9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex.
Next Document:  The Coincidence of Critical Day Length Recognition for Florigen Gene Expression and Floral Transitio...