| Design and patient characteristics of ESHOL study, a Catalonian prospective randomized study. | |
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MedLine Citation:
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PMID: 20602331 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Retrospective studies showed that online hemodiafiltration (OL-HDF) is associated with a risk reduction of mortality over standard hemodialysis (HD) in patients with end-stage renal disease. Until now, no information was available from prospective randomized clinical trials. Methods: A prospective, randomized, multicenter, open study was designed to be conducted in HD units from Catalonia (Spain). The aim of the study is to compare 3-year survival in prevalent end-stage renal disease patients randomized to OL-HDF or to continue on standard HD. The minimum sample size was calculated according to Catalonian mortality of patients on dialysis and assuming a risk reduction associated with OL-HDF of 35% (1-sided p<0.05 and a statistical power of 0.8) and a rate of dropout due to renal transplantation or loss to follow-up of 30%. Results: From May 2007 to September 2008, 906 patients were included and randomized to OL-HDF (n=456) or standard HD (n=450). Demographics and analytical data at the time of randomization were not different between both groups of patients. Patients will be followed during a 3-year period. Conclusion: The present study will contribute to evaluating the benefit for patient survival of OL-HDF over standard HD. |
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Authors:
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Francisco Maduell; Francesc Moreso; Mercedes Pons; Rosa Ramos; Josep Mora-Macià; Andreu Foraster; Jordi Soler; Josep M Galceran; Alberto Martinez-Castelao |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nephrology Volume: 24 ISSN: 1724-6059 ISO Abbreviation: J. Nephrol. Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-03-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: Italy |
Other Details:
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Languages: eng Pagination: 196-202 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Hospital Clínic, Barcelona - Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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