Document Detail


Design of a new somatosensory stimulus delivery device for measuring laryngeal mechanosensory detection thresholds in humans.
MedLine Citation:
PMID:  19272888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Laryngeal control is essential for airway protection, breathing, deglutition, speech, and voice. Unfortunately, integration of laryngeal sensory assessment in research and clinical practice is limited by technical and practical limitations of commercially available technology. A commercial device is available, but reported limitations include procedural complexity requiring two or three individuals to operate, limited stimulus dynamic range, device generated noise, and questionable stimulus reproducibility. The objective of this study was to design a new laryngeal somatosensory stimulus delivery device that provides direct, reliable control over the timing, duration, and dynamic range of stimulus presentation, and test the device in individuals who may manifest a laryngeal sensory deficit. The new device operates silently and has more than four times greater stimulus dynamic range than the commercial device. Testing with the new device revealed laryngeal mechanosensory detection thresholds in an individual with Parkinson's disease that were seven times higher than those of healthy controls. These data would have otherwise gone undetected due to limited stimulus dynamic range in the commercial device. The new design resulted in a new assessment instrument that is simple to use for routine clinical assessment, yet sufficiently versatile for integration within rigorous clinical research protocols.
Authors:
Michael J Hammer
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-10-31
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  56     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-08     Completed Date:  2009-07-24     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1154-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Differential Threshold
Electric Stimulation / instrumentation*
Equipment Design
Humans
Laryngeal Diseases / diagnosis*,  etiology
Laryngoscopes
Larynx / physiology*
Mechanoreceptors / metabolism
Mechanotransduction, Cellular / physiology
Parkinson Disease / complications
Plethysmography
Reference Values
Reproducibility of Results
Grant Support
ID/Acronym/Agency:
DC007260/DC/NIDCD NIH HHS; F31 DC007260/DC/NIDCD NIH HHS; F31 DC007260-01/DC/NIDCD NIH HHS; F31 DC007260-02/DC/NIDCD NIH HHS; KL2 RR025012/RR/NCRR NIH HHS; KL2 RR025012-01/RR/NCRR NIH HHS; KL2 RR025012-02/RR/NCRR NIH HHS; RR025012/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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